Test: GRE Subject Test: Biochemistry, Cell, and Molecular Biology

1.

Which of the following mutations in the EGF pathway could lead to increased proliferation of cells?

Mutation abolishing kinase activity of RAF

Mutation blocking EGF binding to EGFR

Mutation introducing hydrophillic domains in the hydrophobic region of EGFR 

Mutation causing constitutively phosphorylated Erk

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