Test: Biochemistry

1.

A drug is introduced into cells that affects the mechanics of the electron transport chain. Specifically, this drug completely inhibits the flow of electrons through the electron transport chain and also completely halts the synthesis of ATP. Which of the following drugs is capable of doing this, and how is it accomplished?

Dinitrophenol, which acts as a proton uncoupler by shuttling protons across the inner mitochondrial membrane

Methotrexate, which acts as a competitive inhibitor of dihydrofolate reductase

Oligomycin, which inhibits ATP synthase

Cyanide, which inhibits the activity of cytochrome C oxidase

Allopurinol, which acts as a suicide inhibitor of xanthine oxidase

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