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Test: MCAT Biology
Type II diabetes results from defective pancreatic beta cells and increased insulin resistance, indicating that peripheral tissues (such as skeletal muscle) do not properly respond to insulin.
Mouse models have been developed to model type II diabetes. In addition to global mutations, tissue-specific mutations can be used to delete genes of interest in precise regions of the body. A group of investigators is interested in characterizing the role of the gene Dia in the onset of diabetes.
Four groups of male mice are compared. Group A is a control group, group B has a global deletion of Dia, group C has a beta cell-specific Dia mutation, and group D has a skeletal muscle-specific Dia mutation.
In order to measure the ability of these mice to respond to a glucose challenge, the mice are fasted overnight. Following the fast, their blood glucose levels are measured (in mg/dL). The mice are then injected with two grams of glucose, and blood glucose levels are measured at 30, 60, 90, and 120 minutes post-injection.
|
|
0 min |
30 min |
60 min |
90 min |
120 min |
|
Group A |
80 |
150 |
120 |
90 |
80 |
|
Group B |
90 |
220 |
180 |
160 |
140 |
|
Group C |
100 |
260 |
190 |
150 |
135 |
|
Group D |
75 |
145 |
110 |
90 |
75 |
| 1. | Assuming proper experimental design, which groups have impaired glucose clearance? |
Group B
Group C
Group D
Groups A and D
Groups B and C
