Biochemistry : Ligases

Study concepts, example questions & explanations for Biochemistry

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Example Questions

Example Question #1 : Ligases

Which of the following correctly mentions the function of a common eukaryotic ligase?

Possible Answers:

Catalyze the conversion of glucose-6-phosphate into fructose-6-phosphate 

Convert pyruvate into acetyl-coenzyme A

Join lagging strands (Okazaki fragments) of DNA during replication 

Transfer amino groups from an amino acid to an alpha-keto acid

Convert adenosine to adenine and ribose in the presence of water

Correct answer:

Join lagging strands (Okazaki fragments) of DNA during replication 

Explanation:

Mammalian DNA ligase I has this function, and there are other DNA ligases which perform it in other animals and eukaryotes (prokaryotes also have their own DNA ligases). All the other functions mentioned are done by other classes of enzymes, not ligases (i.e. hydrolases, aminotransferases, oxidoreductases, etc.).

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