Test: High School Biology

DNA is naturally found as a double-helix, but for it to replicated it must first be unwound so that DNA replication proteins can access the two strands. The double-helix structure of DNA is very stable, and after being unwound for DNA replication to occur, the two strands can easily return to the double-helix structure. If the strands re-anneal, proteins necessary for DNA replication cannot enter and begin the process of replication.

1.

Which of the following pairs of DNA replication proteins is responsible for unwinding the DNA double-helix and maintaining the separation of the DNA strands?

DNA polymerase and DNA ligase

DNA ligase and helicase

Single-strand binding protein (SSB) and helicase

DNA polymerase and helicase

Helicase and single-strand binding protein (SSB)

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