Systems Physiology

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Anatomy › Systems Physiology

Questions 1 - 10
1

Which of the following correctly describes systole and diastole?

During diastole the atria contract and the ventricles are filling. During systole the ventricles contract and the atria are relaxed and filling

During diastole the ventricles contract and the atria are filling. During systole the atria contract and the ventricles are relaxed and filling

None of these

All chambers are relaxed during diastole and all chambers contract during systole

The left and atrium and ventricle are relaxed during diastole, while the right atrium and ventricle are contracting during systole

Explanation

The heart has four chambers. During diastole the atria contract to push blood into the ventricles, which are relaxed, but during systole the atria relax to fill with blood while the ventricles contract. This alternating contraction moves blood through the heart, the pulmonary circulatory path, and eventually out of the heart.

When the atria contract during diastole, blood is moving into the right ventricle and also into the left ventricle. During systole when the ventricles contract, blood is moving from the right ventricle towards the pulmonary circuit and from the left ventricle to the rest of the body.

2

A scientist is examining a sample of tissue taken from a skeletal muscle biopsy. Which of the following is most likely true of sample?

The cells have well-developed sarcoplasmic reticulum for storing calcium cations

The cells have well-developed sarcoplasmic reticulum for storing sodium cations

The cells have well-developed endoplasmic reticulum for storing calcium cations

The cells have well-developed sarcoplasmic reticulum for storing potassium cations

The cells have well-developed endoplasmic reticulum for storing potassium cations

Explanation

The sarcoplasmic reticulum is a specialized cell structure, characteristic of skeletal muscle cells, that is used to store calcium ions.

Upon neural stimulation, depolarization of the T-tubules causes a cellular reaction to open ion channels in the membrane of the sarcoplasmic reticulum. Calcium is released into the cell, where it can bind to troponin and allow for muscle contraction.

The endoplasmic reticulum is found in most eukaryotic cells, and is used for lipid synthesis, detoxification, and several other functions. Sodium and potassium play significant role in regulating membrane potential, but are not stored in the muscle cell in large amounts as calcium is.

3

When measuring the heat generated by muscle contraction, there is an additional amount of heat, labelled as 'unexplained heat.'

What is the source of the 'unexplained heat' in the initial phase of muscle contraction?

Calcium that is released by the sarcoplasmic reticulum binds to parvalbumin in an exothermic binding reaction, producing the 'unexplained heat.'

The release of calcium from the sarcoplasmic reticulum is an exothermic reaction that produces large amounts of 'unexplained heat.'

All of the answers contribute to 'unexplained heat' production.

Parvalbumin directly catalyzes the breakdown of ATP, producing the 'unexplained heat' phenomenon that is observed.

There is no such thing as 'unexplained heat' related to muscle contraction.

Explanation

The signal for muscle contraction causes the release of calcium from the sarcoplasmic reticulum. This calcium floods the cell and is necessary for causing muscle contraction. Parvalbumin, a protein in the cytoplasm, binds to calcium and acts as a slow-releaser of calcium. This binding reaction of calcium with parvalbumin causes the release of heat, which is termed as 'unexplained heat.' The 'unexplained heat' is also known as 'labile heat.'

4

Which of the following is not a long bone?

Axis

Second metatarsal

Humerus

Fibula

Explanation

The axis is the only bone listed that is not a long bone. The axis is the second cervical vertebra (C2) and is classified as an irregular bone.

5

Which of the following is NOT a property of neurons?

Undergo reactive gliosis in response to injury

Permanent cells

Cells do not divide during adulthood

Compose the nervous system

Explanation

Neurons are the cells that make up the nervous system. Neurons are large, permanent cells that do not divide during adulthood and spend most of their lives in the G0 phase of the cell cycle. If part of a neuron is damaged, it undergoes Wallerian degeneration, meaning that the neuron degenerates distal to the injury, and does not undergo reactive gliosis in response to injury. Astrocytes, a type of glial cell, do this.

6

Which of the following is a feature of the sympathetic nervous system?

Some sympathetic fibers pass through the paravertebral ganglia of the sympathetic trunk; other sympathetic fibers synapse there

Some sympathetic fibers leave the central nervous system (CNS) by specific cranial nerves

Sympathetic fibers exit the spinal cord by dorsal roots of spinal nerves

Sympathetic stimulation causes dilation of blood vessels in the skin of the back and limbs

Explanation

The sympathetic nervous system is one of two divisions of the autonomic nervous system; it is responsible for the "fight or flight" response and is involved in homeostasis. Some sympathetic fibers pass through the paravertebral ganglia of the sympathetic trunk, while other sympathetic fibers synapse there.

Parasympathetic nerves are associated with cranial nerves, and the dilation of blood vessels in skin of the back and limbs (the sympathetic system constricts these vessels). Preganglionic neurons originate in the thoracolumbar region of the spinal cord (T2 to L1) then travel to a paravertebral ganglion or prevertebral ganglion, where they synapse with a postganglionic neruon. The paravertebral ganglion are found throughout the length of the spinal cord, including the cervical, thoracic, lumbar, and sacral areas.

7

Which type of neuroglial cell is star-shaped and takes up 50% of the cells in the brain?

Astrocytes

Oligodendrocytes

Schwann Cells

Microglia cells

Ependymal cells

Explanation

Astrocytes are star-shaped cells found between neurons and blood vessels. They cover almost all of the capillaries in the brain and make contact with surfaces of neurons. They make up approximately 50% of the cells in the brain. Astrocytes are responsible for supporting neurons by maintaining the extracellular fluid, facilitating nutrient delivery and waste removal to and from neurons, maintaining the blood-brain barrier, and repairing damaged cells in the central nervous system. Schwann cells and oligodendrocytes are responsible for myelinating axons in the peripheral nervous system and central nervous system, respectively. Microglia are specialized macrophages that remove cellular debris, infectious agents and damaged neurons. Ependymal cells are epithelial-like glial cells in the central nervous system that line the ventricles and produce cerebrospinal fluid.

8

A scientist is examining a sample of tissue taken from a skeletal muscle biopsy. Which of the following is most likely true of sample?

The cells have well-developed sarcoplasmic reticulum for storing calcium cations

The cells have well-developed sarcoplasmic reticulum for storing sodium cations

The cells have well-developed endoplasmic reticulum for storing calcium cations

The cells have well-developed sarcoplasmic reticulum for storing potassium cations

The cells have well-developed endoplasmic reticulum for storing potassium cations

Explanation

The sarcoplasmic reticulum is a specialized cell structure, characteristic of skeletal muscle cells, that is used to store calcium ions.

Upon neural stimulation, depolarization of the T-tubules causes a cellular reaction to open ion channels in the membrane of the sarcoplasmic reticulum. Calcium is released into the cell, where it can bind to troponin and allow for muscle contraction.

The endoplasmic reticulum is found in most eukaryotic cells, and is used for lipid synthesis, detoxification, and several other functions. Sodium and potassium play significant role in regulating membrane potential, but are not stored in the muscle cell in large amounts as calcium is.

9

What are the two gates of the voltage-gated channels along the axonal plasma membrane?

Activation and inactivation

Activation and reactivation

and

Positive and negative

Explanation

The voltage-gated channels along the axonal plasma membrane open and close in response to changes in voltage, and may exist in three distinct states: deactivated, activated, and inactivated. While the axon is at rest, these channels are said to be deactivated; they are impermeable to sodium ions since their activation gates are closed. Once the neuron gets depolarized to the threshold of the voltage-gated sodium channels, the activation gates open, allowing the influx of sodium down its concentration gradient into the cell. During this time the channels are in their activated state. At the peak of the action potential the activation gates are still open, but the inactivation gates close, stopping the flow of sodium through the channels. The channels are in the inactivated state due to the cell becoming depolarized. Once the membrane potential drops back down towards resting, the inactivation gates open, and the activation gates close, thereby deactivating the channels again, until another action potential depolarizes the membrane.

10

Which of the following is not a long bone?

Axis

Second metatarsal

Humerus

Fibula

Explanation

The axis is the only bone listed that is not a long bone. The axis is the second cervical vertebra (C2) and is classified as an irregular bone.

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