Systems Physiology

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Anatomy › Systems Physiology

Questions 1 - 10
1

On an EKG, which recording represents atrial depolarization?

P wave

T wave

QRS complex

U wave

X wave

Explanation

The P wave represents atrial depolarization. The QRS complex represents ventricular depolarization, the T wave represents repolarization, and the U wave (if present) represents late ventricular repolarization (e.g. repolarization of bundle branches). There are no X waves on an EKG.

2

What in one defining characteristic of veins?

They carry blood from capillaries to the heart

They carry blood from the heart to the capillaries

They carry deoxygenated blood from capillaries to the heart

They carry deoxygenated blood from the heart to the capillaries

They have a muscular layer allowing them to expand and contract, thus regulating blood pressure

Explanation

Veins always carry blood towards the heart. The blood in veins is mostly deoxygenated, however the pulmonary vein, which goes from the lungs to the left atrium, carries newly oxygenated blood back to the heart for it to be pumped to the rest of the body.

In contrast, arteries always travel away from the heart and usually carry oxygenated blood, with the exception of the pulmonary arteries. Arteries and arterioles have a thick layer of smooth muscle that helps to regulate blood pressure. Veins may have some smooth muscle, but are not nearly as significant in helping to regulate blood flow.

3

What are the two gates of the voltage-gated channels along the axonal plasma membrane?

Activation and inactivation

Activation and reactivation

and

Positive and negative

Explanation

The voltage-gated channels along the axonal plasma membrane open and close in response to changes in voltage, and may exist in three distinct states: deactivated, activated, and inactivated. While the axon is at rest, these channels are said to be deactivated; they are impermeable to sodium ions since their activation gates are closed. Once the neuron gets depolarized to the threshold of the voltage-gated sodium channels, the activation gates open, allowing the influx of sodium down its concentration gradient into the cell. During this time the channels are in their activated state. At the peak of the action potential the activation gates are still open, but the inactivation gates close, stopping the flow of sodium through the channels. The channels are in the inactivated state due to the cell becoming depolarized. Once the membrane potential drops back down towards resting, the inactivation gates open, and the activation gates close, thereby deactivating the channels again, until another action potential depolarizes the membrane.

4

The autonomic nervous system consists of three divisions.

Which of the following is not a division of the autonomic system?

Somatic

Sympathetic

Parasympathetic

Enteric

Explanation

The autonomic nervous system (ANS) consists of a set of pathways to and from the central nervous system (CNS) that innervate and regulate smooth muscle, cardiac muscle, and glands. The ANS is distinct from the somatic nervous system, which innervates skeletal muscle. The ANS has three divisions the sympathetic, parasympathetic, and enteric nervous systems.

5

When measuring the heat generated by muscle contraction, there is an additional amount of heat, labelled as 'unexplained heat.'

What is the source of the 'unexplained heat' in the initial phase of muscle contraction?

Calcium that is released by the sarcoplasmic reticulum binds to parvalbumin in an exothermic binding reaction, producing the 'unexplained heat.'

The release of calcium from the sarcoplasmic reticulum is an exothermic reaction that produces large amounts of 'unexplained heat.'

All of the answers contribute to 'unexplained heat' production.

Parvalbumin directly catalyzes the breakdown of ATP, producing the 'unexplained heat' phenomenon that is observed.

There is no such thing as 'unexplained heat' related to muscle contraction.

Explanation

The signal for muscle contraction causes the release of calcium from the sarcoplasmic reticulum. This calcium floods the cell and is necessary for causing muscle contraction. Parvalbumin, a protein in the cytoplasm, binds to calcium and acts as a slow-releaser of calcium. This binding reaction of calcium with parvalbumin causes the release of heat, which is termed as 'unexplained heat.' The 'unexplained heat' is also known as 'labile heat.'

6

What hormones, secreted by the adrenal medulla, facilitate the fight or flight response?

Epinephrine and norepinephrine

Triiodothyronine and thyroxine

Estrogen and progesterone

Gastrin and secretin

Explanation

The adrenal medulla produces epinephrine and norepinephrine, which cause the fight or flight response. The thyroid gland produces triiodothryonine and thyroxine, which are used for metabolism, growth, and development. The ovaries and placenta produce estrogen and progesterone, which are used for fetal/maternal development and egg production. Lastly, the stomach and small intestines produce gastrin and secretin, which are used to assist digestion and nutrient absorption.

7

Which of the following parts of the bones is found most deep to all of the other layers?

endosteum

periosteum

cancellous bone

compact bone

spongy bone

Explanation

The endosteum is the layer that is found deep to all layers. It is found in the inner lining of the bone. Meanwhile, the periosteum is the most superficial layer of the bone which compromises the outer covering of bones.

8

Where do the nuclei of the parasympathetic nervous system originate?

Craniosacral region (cranial nerves and S2-S4)

Thoracolumbar (T1-L3) and S2-S4

S2-S4 only

Thoracolumbar region (T1-L3)

Explanation

Preganglionic neurons of the parasympathetic nervous system originate in the nuclei of the craniosacral region (cranial nerves and in the spinal cord segments of S2-S4). Those of the sympathetic nervous system originate in the thoracolumbar region (spinal cord segments of T1-L3).

9

Which of the following correctly describes systole and diastole?

During diastole the atria contract and the ventricles are filling. During systole the ventricles contract and the atria are relaxed and filling

During diastole the ventricles contract and the atria are filling. During systole the atria contract and the ventricles are relaxed and filling

None of these

All chambers are relaxed during diastole and all chambers contract during systole

The left and atrium and ventricle are relaxed during diastole, while the right atrium and ventricle are contracting during systole

Explanation

The heart has four chambers. During diastole the atria contract to push blood into the ventricles, which are relaxed, but during systole the atria relax to fill with blood while the ventricles contract. This alternating contraction moves blood through the heart, the pulmonary circulatory path, and eventually out of the heart.

When the atria contract during diastole, blood is moving into the right ventricle and also into the left ventricle. During systole when the ventricles contract, blood is moving from the right ventricle towards the pulmonary circuit and from the left ventricle to the rest of the body.

10

Atropine is a molecule that is an antagonist to muscarinic cholinergic receptors. Based on your knowledge of autonomic nervous system physiology, how would you expect the pupils to respond to topical administration of atropine?

You will observe mydriasis (pupil dilation)

You will observe miosis (pupil constriction)

There will be no change in pupil size because the pupils do not have muscarinic receptors

The iris sphincter muscles would experience a relaxed paralysis

The iris sphincter muscles would experience a contracted paralysis

Explanation

The pupillary sphincter muscles contain muscarinic cholinergic receptors that help the eyes to respond to parasympathetic tone. When this parasympathetic signal is blocked (antagonized) via atropine, you will observe a "sympathetic response" at the level of the pupil. In this scenario, you would observe the sympathetic response of pupil dilation. Hint: "aTROP'ine" and "seeing a TROPical setting" both cause your pupils to dilate nice and wide!

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