Adverse Effects And Drug Interactions

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NCLEX-RN › Adverse Effects And Drug Interactions

Questions 1 - 10
1

A 57-year-old client is started on enalapril for hypertension in an outpatient clinic. Two days later the client calls reporting swelling of the lips and tongue and difficulty swallowing; no rash is noted. What finding requires IMMEDIATE intervention to prevent further complications?

Dry cough that occurs occasionally at night

Mild dizziness when standing quickly

Swelling of lips and tongue after starting enalapril

Blood pressure of 138/84 mmHg at home

Explanation

This question tests understanding of adverse effects and drug interactions, particularly angioedema from ACE inhibitors. The key findings are swelling of lips and tongue with difficulty swallowing shortly after starting enalapril, indicating angioedema. Immediate intervention is required to prevent airway obstruction. Dizziness, dry cough, and slightly elevated BP are common and less urgent. Assessment of airway patency is vital. The nursing process prioritizes emergency response. A transferable strategy is to monitor for angioedema in the first weeks of ACE inhibitor therapy.

2

A 63-year-old client in an outpatient clinic takes sildenafil as needed and is prescribed nitroglycerin sublingual tablets for new episodes of chest pain. The client states, “I took sildenafil last night.” Current vital signs are BP 96/58 mmHg, HR 92/min, and the client reports dizziness when standing. What is the nurse's PRIORITY action when noticing a drug interaction?

Teach the client to take nitroglycerin and then drive to the pharmacy to pick up aspirin

Advise the client to increase fluid intake and continue both medications as prescribed

Recommend taking sildenafil daily to prevent chest pain

Instruct the client to avoid taking nitroglycerin and notify the provider due to risk of severe hypotension

Explanation

This question tests understanding of adverse effects and drug interactions. The key assessment findings include the client's recent use of sildenafil, prescription for nitroglycerin, low blood pressure of 96/58 mmHg, heart rate of 92/min, and dizziness upon standing, indicating potential orthostatic hypotension. The correct answer, option A, is the best choice because sildenafil and nitroglycerin both cause vasodilation, which can lead to severe hypotension, prioritizing client safety by instructing avoidance of nitroglycerin and notifying the provider for alternative management. Option B is incorrect as administering nitroglycerin could worsen hypotension and driving to the pharmacy is unsafe given the client's symptoms; option C is wrong because sildenafil is not indicated for preventing chest pain and daily use is inappropriate; option D is less optimal as continuing both medications ignores the dangerous interaction, and increasing fluids does not address the root cause of the risk. In the nursing process, this involves thorough assessment of medication history and vital signs to identify interactions, followed by immediate intervention to prevent adverse events. Decision-making in medication safety requires prioritizing actions that mitigate life-threatening risks like severe hypotension. A transferable strategy for managing medication-related issues is to routinely educate clients on potential drug interactions and encourage them to report all medications to healthcare providers before starting new prescriptions.

3

A 66-year-old client with chronic obstructive pulmonary disease uses an albuterol inhaler and is started on propranolol for tremor. At follow-up in an outpatient clinic, the client reports increased shortness of breath and wheezing not relieved by albuterol. Which medication should the nurse QUESTION for a client with these symptoms?

Inhaled albuterol used as needed

Propranolol therapy in a client with COPD using albuterol

Inhaled corticosteroid used daily

Normal saline nasal spray used for dryness

Explanation

This question tests understanding of adverse effects and drug interactions, focusing on beta-blockers antagonizing beta-agonists in COPD. The key symptoms are increased shortness of breath and wheezing unrelieved by albuterol in a client on propranolol, due to bronchoconstriction. Questioning propranolol in a COPD client using albuterol is appropriate as nonselective beta-blockers worsen symptoms. Albuterol, corticosteroids, and saline are standard. Assessment of respiratory response is essential. The nursing process emphasizes evaluating therapy efficacy. A transferable strategy is to use cardioselective beta-blockers in respiratory conditions.

4

A 76-year-old client in long-term care is taking donepezil for Alzheimer disease and is started on oxybutynin for urinary urgency. Over the next week, staff report increased confusion and the client has a dry mouth and constipation. What is the nurse's PRIORITY action when noticing a drug interaction?

Notify the provider that oxybutynin may worsen cognition and counteract donepezil

Administer an over-the-counter sleep aid at bedtime for agitation

Limit oral fluids to decrease urinary frequency

Increase the donepezil dose to overcome the urinary medication effects

Explanation

This question tests understanding of adverse effects and drug interactions, specifically anticholinergic effects counteracting cholinesterase inhibitors. The key findings are increased confusion, dry mouth, and constipation in a client on donepezil and oxybutynin, indicating antagonism. Notifying the provider that oxybutynin may worsen cognition and counteract donepezil is priority for safety and symptom management. Increasing donepezil risks side effects; limiting fluids worsens constipation; sleep aids add anticholinergics. Assessment of cognitive changes is key. The decision-making principle is to avoid opposing mechanisms. A transferable strategy is to review anticholinergic burden in dementia clients.

5

A 29-year-old postpartum client in an outpatient clinic started a combined oral contraceptive pill 2 weeks ago and is taking rifampin for tuberculosis. The client reports breakthrough bleeding and is concerned about pregnancy risk. What is the nurse's PRIORITY action when noticing a drug interaction?

Recommend doubling the oral contraceptive dose without consulting the provider

Reassure the client that rifampin increases contraceptive effectiveness

Instruct the client to stop rifampin immediately

Teach the client to use a backup nonhormonal contraceptive method while taking rifampin

Explanation

This question tests understanding of adverse effects and drug interactions, particularly reduced contraceptive efficacy from enzyme inducers. The key concern is breakthrough bleeding and pregnancy risk in a client on oral contraceptives and rifampin, due to induced metabolism. Teaching to use backup contraception is priority to prevent unintended pregnancy safely. Reassuring increased effectiveness is incorrect; stopping rifampin risks TB; doubling dose is unsafe without orders. Assessment involves recognizing interaction effects. The decision-making principle is client education on risks. A transferable strategy is to counsel on alternative contraception with inducers.

6

A 79-year-old client in a hospital unit takes digoxin for heart failure and was started on furosemide yesterday for fluid overload. This morning the client reports nausea and sees “yellow halos” around lights; apical pulse is 52/min and potassium is 3.1 mEq/L (normal 3.5–5.0). What is the nurse's PRIORITY action?

Hold digoxin and notify the provider of possible digoxin toxicity related to hypokalemia

Encourage the client to restrict fluids to 1 liter per day

Administer an antacid for nausea and reassess in 1 hour

Administer the scheduled digoxin dose to improve cardiac output

Explanation

This question tests understanding of adverse effects and drug interactions, particularly digoxin toxicity exacerbated by hypokalemia from diuretics. The key findings are nausea, visual halos, bradycardia, and low potassium in a client on digoxin and furosemide, signaling toxicity. Holding digoxin and notifying the provider is priority to prevent arrhythmias and address hypokalemia safely. Administering digoxin worsens toxicity; restricting fluids is inappropriate; antacids don't address the cause. Assessment of electrolyte and cardiac status is vital. The decision-making principle is to withhold drugs in toxicity signs. A transferable strategy is to monitor potassium levels when using digoxin with loop diuretics.

7

A 70-year-old client with chronic back pain takes oxycodone as needed and was newly prescribed lorazepam for anxiety. In a medical-surgical unit, the nurse finds the client difficult to arouse with slurred speech; vital signs are BP 102/60 mmHg, HR 54/min, RR 8/min, SpO2 90% on room air. What is the nurse's PRIORITY action when noticing a drug interaction?

Hold further sedating medications and support ventilation while notifying the provider/rapid response team

Offer a snack and recheck blood glucose in 30 minutes

Encourage the client to ambulate with assistance to improve alertness

Administer the next scheduled dose of lorazepam to prevent withdrawal

Explanation

This question tests understanding of adverse effects and drug interactions, particularly respiratory depression from opioid-benzodiazepine combinations. The key findings are difficulty arousing, slurred speech, bradypnea, and low SpO2 in a client on oxycodone and lorazepam, suggesting sedation overdose. Holding sedating medications, supporting ventilation, and notifying the provider or rapid response team is priority to prevent respiratory arrest. Ambulating may increase fall risk; offering a snack addresses hypoglycemia not indicated; administering more lorazepam worsens sedation. Assessment of respiratory status is crucial in polypharmacy. The decision-making principle is to prioritize reversal of life-threatening effects. A transferable strategy is to monitor sedation levels when combining CNS depressants.

8

A 74-year-old client in a medical-surgical unit takes metoprolol for hypertension and is started on diltiazem for atrial fibrillation rate control. Shortly after the first dose of diltiazem, the client becomes lightheaded; vital signs are BP 88/56 mmHg, HR 38/min. What is the nurse's PRIORITY action when noticing a drug interaction?

Reassess vital signs in 4 hours to see if symptoms resolve

Hold further doses and notify the provider of symptomatic bradycardia and hypotension

Encourage the client to drink caffeinated beverages to raise heart rate

Give the next scheduled metoprolol dose to stabilize the heart rhythm

Explanation

This question tests understanding of adverse effects and drug interactions, particularly additive bradycardia and hypotension from beta-blockers and calcium channel blockers. The key findings are lightheadedness, hypotension, and bradycardia in a client on metoprolol and diltiazem, indicating hemodynamic compromise. Holding doses and notifying the provider is priority to prevent syncope or shock. Giving more metoprolol worsens effects; caffeine is inappropriate; reassessing later delays care. Assessment of vital signs is essential. The decision-making principle is to avoid additive AV node suppression. A transferable strategy is to monitor heart rate closely with combined rate controllers.

9

A 55-year-old client with chronic kidney disease takes lisinopril and is newly prescribed trimethoprim-sulfamethoxazole for a skin infection. Two days later the client reports weakness; labs show potassium 5.9 mEq/L (normal 3.5–5.0). Which medication should the nurse QUESTION for a client with these symptoms?

Acetaminophen taken for discomfort

Trimethoprim-sulfamethoxazole added to lisinopril therapy

Polyethylene glycol taken for constipation

Topical mupirocin applied to the wound

Explanation

This question tests understanding of adverse effects and drug interactions, focusing on hyperkalemia from ACE inhibitors and certain antibiotics. The key finding is elevated potassium with weakness in a client on lisinopril and trimethoprim-sulfamethoxazole, especially with kidney disease. Questioning trimethoprim-sulfamethoxazole added to lisinopril is appropriate as this combination risks hyperkalemia. Mupirocin, acetaminophen, and polyethylene glycol are safe. Assessment of electrolytes in renal clients is essential. The nursing process prioritizes lab monitoring. A transferable strategy is to choose alternative antibiotics in hyperkalemia risk.

10

A 62-year-old client in an outpatient clinic takes allopurinol for gout and is started on azathioprine after a kidney transplant. Within a week, the client develops fever and sore throat; labs show white blood cell count 2.1 × $10^3$/µL (normal 4.5–11.0). Which medication should the nurse QUESTION for a client with these symptoms?

Docusate sodium for constipation prevention

Topical hydrocortisone cream for itching

Azathioprine prescribed while the client is taking allopurinol

Calcium citrate supplement

Explanation

This question tests understanding of adverse effects and drug interactions, specifically bone marrow suppression from azathioprine potentiated by allopurinol. The key findings are fever, sore throat, and low WBC in a client on allopurinol and azathioprine, indicating myelosuppression. Questioning azathioprine with allopurinol is appropriate as this interaction increases toxicity risk. Calcium, docusate, and hydrocortisone are safe. Assessment of blood counts is vital in immunosuppression. The nursing process prioritizes infection signs. A transferable strategy is to dose-adjust immunosuppressants with xanthine oxidase inhibitors.

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