Side Effects

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NCLEX-PN › Side Effects

Questions 1 - 10
1

You are the nurse in a primary care clinic taking care of a 26-year old female with a urinary tract infection. You are counseling her about taking her antibiotic, cephalexin. You warn her that a common side effect is which of the following?

Diarrhea

Necrotizing skin rash

Headache

Hair loss

Pharyngitis

Explanation

The correct answer is "diarrhea." Diarrhea is a common side effect associated with antibiotic use, including cephalexin. This diarrhea is typically self-limited and resolves within the first day or two of administration. Sometimes patients are advised to take a probiotic or consume yogurt when starting a new antibiotic if they experienced diarrhea when starting antibiotics in the past.

Neither headaches, hair loss, pharyngitis, nor necrotizing skin rash are known common side effects of cephalexin use.

2

Which of the following is a symptom of digoxin toxicity?

Nausea, vomiting, and diarrhea

Rash

Tremor

Mood swings

Explanation

Nausea, vomiting, and diarrhea are common symptoms of digoxin toxicity. Other symptoms may include confusion, anorexia, irregular heartbeat, and palpitations. Tremors, mood swings, and rash are not generally seen with digoxin toxicity.

3

You are the nurse in a dermatology clinic taking care of a 22-year old female with severe nodular acne. She is going to start isotretinoin therapy after this appointment. She should be strictly advised to avoid which of the following?

Pregnancy

Eating bananas

Eating grain products

Drinking juices

Taking NSAID's

Explanation

The correct answer is "pregnancy." Patients initiating isotretinoin therapy should all be strictly advised to avoid becoming pregnant, and must absolutely not be started on isotretinoin therapy if they are actively pregnant. Isotretinoin is a potent teratogenic agent, and could cause devastating effects to a developing fetus, including but not limited to termination of the pregnancy. Any female patient who is going to start isotretinoin therapy must be tested for pregnancy immediately prior to therapy and repeatedly throughout treatment.

There is no known significant interaction between isotretinoin and NSAID use. Likewise, there is no reason why a patient on isotretinoin must avoid bananas, grains, or juices.

4

You are the nurse taking care of a patient with a history of schizophrenia, not on any medications, who is being admitted for disorganized thoughts, paranoid delusions, auditory hallucinations, and combative behavior. The physician orders a dose of haloperidol to be administered. Prior to giving the haloperidol, you suggest that which of the following be done?

Obtain an electrocardiogram (ECG)

Obtain a chest x-ray

Obtain a CT abdomen

Obtain a blood glucose level

Contact the authorities to detain the patient since he/she is being combative

Explanation

The correct answer is "Obtain an electrocardiogram (ECG)."

This question tests your knowledge of the major side effects of the first-generation anti-psychotic medication, haloperidol, also known as Haldol. Some of the major side effects of haloperidol include extrapyramidal symptoms, anticholinergic symptoms, blood pressure changes, and hypersomnolence.

In addition, haloperidol has the potential to prolong the QTc interval on an ECG. QTc prolongation can be particularly dangerous in patients who already have a prolonged QTc interval due to a pre-existing medical condition (e.g. Long QT Syndrome), or medications they are already taking. A prolonged QTc interval has the potential to progress on ECG to more dangerous arrhythmias including torsades de pointes and ventricular fibrillation/tachycardia, which can be fatal. Therefore, it is imperative to check a patient's QTc interval on an ECG prior to administering haloperidol to confirm that they do not already have a prolonged QTc interval.

While this patient's blood glucose is not necessarily going to be normal, that is not something that needs to be emergently checked prior to haloperidol administration.

There is no indication to obtain a chest x-ray or CT abdomen prior to haloperidol administration.

It would be inappropriate to contact the authorities to detain this acutely psychotic patient with schizophrenia, as the patient is already in the hospital and in the care of a psychiatric medical team. Further, even though the patient is combative, if necessary, the medical team is allowed to place the patient in restraints without the need for police intervention. There is no evidence that any members of the care team are in acute danger.

5

You are the nurse taking care of a patient with severe hip pain that is unresponsive to acetaminophen and NSAIDs. You are prepare a dose of hydromorphone and describe potential side effects to the patient. Which of the following side effects should you warn the patient about?

Pruritis

Hair loss

Pharyngitis

Diarrhea

Foot pain

Explanation

The correct answer is "pruritis." Pruritis, or itching, is a fairly common side effect of opioid medication use, and hydromorphone, also known as Dilaudid, is a potent opioid. As such, patients should be advised of this potential side effect prior to initiation of therapy, and should be advised to inform the nursing or medical care team if they experience pruritis, as dosing can be adjusted, and/or additional medications may be added to control the itchiness.

Neither hair loss, foot pain, pharyngitis, nor diarrhea are side effects known to be associated with opioid use.

6

Which of the following is the most serious potential adverse effect of enalapril?

Angioedema

Nausea and vomiting

Dry cough

Low blood pressure

Explanation

All of these are potential side effects of ACE (angiotensin-converting enzyme) inhibitors such as enalapril, but angioedema (the swelling of the face, lips, and/or tongue) is a potentially life threatening condition, as swelling can obstruct the airway.

7

A male client is receiving 150mg of gentamicin every 8 hours for a soft tissue infection. The nurse giving this medication is aware there are several serious side effects associated with gentamicin, including ototoxicity.

Which statement by the client indicates that he may be experiencing this serious side effect?

"I have a high pitch ringing sound in my ear"

"I am feeling nauseous"

"I have a metallic taste in my mouth"

"There is a severe rash on my neck and chest"

"I am having difficulty swallowing"

Explanation

The ringing in the ear is tinnitus, which is indicative of ototoxicity. Nausea, metallic taste in mouth, difficulty swallowing and skin reactions are not associated with the development of ototoxicity.

8

Which of the following antibiotics is potentially ototoxic and may cause irreversible hearing loss?

Gentamicin

Penicillin

Doxycycline

Azithromycin

Explanation

Gentamicin is an aminoglycoside antibiotic. Most antibiotics in the aminoglycoside class can have significant ototoxic effects. Of these, streptomycin and gentamicin are primarily toxic to the vestubular system, while amikacin, neomycin, dihydrosterptomycin, and kanamicin primarily affect the cochlea. None of the other antibiotics listed are generally associated with ototoxicity.

9

You are the nurse taking care of a patient with intractable back pain. You are about to administer a dose of oxycodone and are describing possible side effects to the patient. Which of the following common side effects should you warn the patient about?

Constipation

Serotonin syndrome

Headache

Tinnitus

Blindness

Explanation

The correct answer is "constipation," as constipation is a very common side effect associated with use of opioid medications, such as oxycodone, especially in patients who have not been frequently treated with opioids in the past. As such, patients are often advised ahead of time about the possibility this side effect and may be started concurrently on stool softeners and colonic motility agents, such as senna and/or docusate.

Blindness, tinnitus (ringing in the ears), headache, and serotonin syndrome all are not known to be associated with use of opioid medications, like oxycodone.

10

What is the most common vitamin deficiency seen in patients taking metformin?

B12

B6

D

K2

Explanation

B12 deficiency is common in patients on metformin, and should be monitored and supplemented either sublingually or intramuscularly.

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