Causes and Treatments of Pediatric Conditions - NCLEX-PN

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Question

What specific enzyme deficiency accounts for 95% of all cases of congenital adrenal hyperplasia?

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Answer

In 21-hydroxylase deficiency, cortisol production is reduced, which in turn causes adrenocorticotropic hormone (ACTH) to increase. The precursors for the cortisol are then shunted into androgen production since these are steroids, and are thus derived from cholesterol.

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