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Medication And Non-Drug Therapy Selection Practice Test

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An 82-year-old man (weight 74 kg) is discharged after a fall and brings his medication bottles for reconciliation. Medical history: atrial fibrillation, heart failure with reduced ejection fraction, osteoarthritis, chronic kidney disease stage 3; allergies: none. Current medications listed: warfarin (variable dosing; last international normalized ratio 2.6), amiodarone 200 mg by mouth daily, carvedilol 12.5 mg by mouth twice daily, lisinopril 10 mg by mouth daily, furosemide 40 mg by mouth daily, spironolactone 25 mg by mouth daily, ibuprofen 600 mg by mouth three times daily for knee pain, acetaminophen 500 mg by mouth as needed. Labs: serum creatinine 1.8 mg/dL (estimated glomerular filtration rate 35 mL/min/1.73 m$^2$), potassium 5.6 mEq/L (high; normal 3.5–5.0), blood pressure 118/70 mmHg. Lifestyle: limited mobility, drinks 1–2 glasses of wine nightly. Which therapy modification is necessary given the patient's lab results?

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