Other Flow Principles - MCAT Chemical and Physical Foundations of Biological Systems

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Diffusion can be defined as the net transfer of molecules down a gradient of differing concentrations. This is a passive and spontaneous process and relies on the random movement of molecules and Brownian motion. Diffusion is an important biological process, especially in the respiratory system where oxygen diffuses from alveoli, the basic unit of lung mechanics, to red blood cells in the capillaries.

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Figure 1 depicts this process, showing an alveoli separated from neighboring cells by a capillary with red blood cells. The partial pressures of oxygen and carbon dioxide are given. One such equation used in determining gas exchange is Fick's law, given by:

ΔV = (Area/Thickness) · Dgas · (P1 – P2)

Where ΔV is flow rate and area and thickness refer to the permeable membrane through which the gas passes, in this case, the wall of the avlveoli. P1 and P2 refer to the partial pressures upstream and downstream, respectively. Further, Dgas­, the diffusion constant of the gas, is defined as:

Dgas = Solubility / (Molecular Weight)^(1/2)

In higher altitudes, a decrease in which factors of Fick's law can change in order to achieve the same flow rate at lower altitudes.

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Answer

It should be known that in higher altitudes, the partial pressure of oxygen falls. That is, the partial pressure in the alveoli will fall. Thus, flow rate will decrease, and we will need changes to increase flow rate.

By looking at Fick's equation, we can see that a decrease in thickness can help restore flow rate. Biologically speaking, this is less likely to happen, and more correctly, hemoglobin concentration and binding affinity to oxygen increases; however, this is extraneous information not needed for the MCAT.

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