Blood Vessels and Vasculature - MCAT Biological and Biochemical Foundations of Living Systems

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Hemoglobin is the principal oxygen-carrying protein in humans. It exists within erythrocytes, and binds up to four diatomic oxygen molecules simultaneously. Hemoglobin functions to maximize oxygen delivery to tissues, while simultaneously maximizing oxygen absorption in the lungs. Hemoglobin thus has a fundamentally contradictory set of goals. It must at once be opitimized to absorb oxygen, and to offload oxygen. Natural selection has overcome this apparent contradiction by making hemoglobin exquisitely sensitive to conditions in its microenvironment.

One way in which hemoglobin accomplishes its goals is through the phenomenon of cooperativity. Cooperativity refers to the ability of hemoglobin to change its oxygen binding behavior as a function of how many other oxygen atoms are bound to the molecule.

Fetal hemoglobin shows a similar pattern of cooperativity, but has unique binding characteristics relative to adult hemoglobin. Fetal hemoglobin reaches higher saturation at lower oxygen partial pressure.

Because of cooperativity, adult and fetal oxygen-hemoglobin dissociation curves appear as follows.

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Beyond its ability to carry oxygen, hemoglobin is also effective as a blood buffer. The general reaction for the blood buffer system of hemoglobin is given below.

H+ + HbO2 ←→ H+Hb + O2

The hemoglobin gene can be the site of catastrophic genetic changes, one of which is the change seen in sickle cell anemia. In this disorder, hemoglobin mutations cause red blood cells to take on a sickled appearance. These cells are less able to flow freely in the blood through tight spaces. Which of the following vessels is most likely to be the site of accumulation of these misshapen cells?

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Answer

With morphological changes, cells are most likely to be caught in regions with the smallest cross sectional area. Though capiallary beds have the highest TOTAL cross sectional area of any vessel bed in the body, individual capillaries are smaller than any other type of blood vessel. The result is that misshapen red blood cells, such as those in sickle cell anemia, can easily get stuck in capillaries.

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