Genetics › Cell Division
p53 is a famous __________, which aids in blocking cell cycle progression and preventing cancer.
tumor suppressor
oncogene
proto oncogene
checkpoint
p53 is a famous tumor suppressor, which blocks cell cycle progression preventing damaged/mutated DNA from being duplicated. Proto oncogenes are normal genes that regulate cell growth and proliferation. Oncogenes are mutated proto oncogenes that lead to unregulated cell proliferation. The checkpoints are in the S, G1, G2/M phases.
In which phase of mitosis do spindle fibers align chromosomes in the middle of the cell nucleus?
Metaphase
Prophase
Anaphase
Telophase
G1
In metaphase, spindle fibers align chromosomes along the middle of the cell nucleus. A good way to remember this is "M" in metaphase stands for middle. In this portion of mitosis, the cell ensures that each daughter cell will receive the appropriate genetic material. Metaphase occurs right before Anaphase.
During cell division, at what phase does the cell separate into two?
ctyokinesis
Anaphase
Metaphase
prophase
Cytokinesis is the last processes of cell replication and division and consists of the cell membrane dividing into two.
Mitosis is the process by which a parent cell divides to produce two daughter cells with identical genetic material. The chromosomes must condense, align, and be pulled apart to complete this process. What is the name of the mitotic phase in which the duplicated sister chromatids are physically pulled apart?
Anaphase
Metaphase
Prophase
Telophase
Cytokinesis
Prophase and metaphase happen before anaphase, and the duplicated chromosomes (sister chromatids) condense and align. During anaphase they are pulled apart and start migrating to opposite cell poles. Telophase and cytokinesis follow anaphase to complete the division of the cell into two new cells.
If a species has a diploid number of 10 chromosomes, how many chromatids would there be in prophase of mitosis?
20
10
5
40
15
Diploid means 2_n_, where n is the number of chromosomes in a particular species. If there are 10 chromosomes, there will be 20 chromatids. For each chromosome there are two chromatids. Since this is before the cells have fully divided, there will be 2 times the number of chromosomes during prophase. Therefore, the answer is 20.
In which phase of cell division does DNA synthesis (replication) occur?
S
G1
G2
S
G0
The S phase is the "synthesis" phase, where DNA is duplicated. Cells that are not dividing are considered to be in the G0 phase, however, they can enter the cell cycle if they receive the proper signals. The S phase occurs before the M phase (mitosis) as the cell begins to prepare for division.
When undergoing Meiosis, at what stages should the dividing cell(s) have 2n?
prophase II, metaphase II, and anaphase II
prophase I, prophase II, metaphase I, and metaphase II
anaphase I and anaphase II
metaphase I and metaphase II
During Meiosis, the cell starts with 2n in interphase, then duplicates its DNA to have 4n throughout prophase I, metaphase I, and anaphase I. The cell then splits in two during telophase/cytokinesis, and there are 2n during prophase II, metaphase II, and anaphase II. The end product after telophase II is 1n.
Which of the following describes a centromere?
the fiber spindle connecting individual chromosomes during mitosis
the last stage of cell division
the center of an individual chromosome
the center of a daughter cell after mitosis
The correct answer here is the fiber connecting the chromosomes in the initial stages of mitosis. Remember that during mitosis, 1 pair of chromosomes becomes 2 new pairs. This requires the pair to split initially, duplicate, then break off into the new cells. The last stage of cell division is called anaphase, not a centromere. A centromere is the middle of a pair of chromosomes, not the individual chromosome. If you chose the daughter cell, remember that centromeres are not describing the new cell itself, but the connection between chromosomes inside the cell.
What best describes spindle fibers?
the fibers that help move/rearrange chromosomes during the later stages of mitosis
only present during mieosis, not mitosis
connect individual chromosomes to make a pair
act as the primer in RNA creation
The correct answer is that they are the fibers that help move the chromosomes towards a certain side of the cell during mitosis. If you chose the option about connecting a pair of chromosomes, remember that this is called a centromere and is also vital in mitosis. If you chose that the spindle fibers are only necessary in meiosis, remember that even in mitosis, fibers are needed to separate the individual chromosomes to form a new cell. Fibers do not act as the primer in RNA production
At which stage is the last checkpoint before cell division begins?
G2
G0
G1
S
G2, or Gap 2 phase, is the third and last subphase of interphase, preceding mitosis. S phase is the phase in which DNA is duplicated and G1 has the first checkpoint. G0 is the phase where cells do not divide anymore, also known as the resting phase.