Ligases

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Biochemistry › Ligases

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1

Which of the following correctly mentions the function of a common eukaryotic ligase?

Join lagging strands (Okazaki fragments) of DNA during replication

Convert pyruvate into acetyl-coenzyme A

Transfer amino groups from an amino acid to an alpha-keto acid

Catalyze the conversion of glucose-6-phosphate into fructose-6-phosphate

Convert adenosine to adenine and ribose in the presence of water

Explanation

Mammalian DNA ligase I has this function, and there are other DNA ligases which perform it in other animals and eukaryotes (prokaryotes also have their own DNA ligases). All the other functions mentioned are done by other classes of enzymes, not ligases (i.e. hydrolases, aminotransferases, oxidoreductases, etc.).

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