Identifying Specific Lipid Structures

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Biochemistry › Identifying Specific Lipid Structures

Questions 1 - 10
1

Which of the following associations about lipids is false?

Triacylglycerols - no hydrophobic fatty acid tails

Phospholipid - hydrophobic fatty acid tail

Steroid - multiple rings

Glycolipids - hydrophobic fatty acid tails

Isoprene - five-carbon atoms

Explanation

Triacylglycerols, like phospholipids and glycolipids, have long, hydrophobic, fatty acid tails. Steroids are characterized by their ABCD ring structure. Isoprene, the building block of steroids and polyisoprenoids, has five carbon atoms.

2

Vt biochem 11 28 15

What is the most accurate description of the given compound?

This compound is a lipid

This compound is a carbohydrate

This compound is a protein

This compound is a nucleic acid

The structure is an amino acid

Explanation

This question is presenting is with the molecular structure of some unknown compound, and is asking us to identify the most appropriate classification for it.

From the picture, we can see that this structure has a carbon backbone. On the carbon backbone, we have three long hydrocarbon chains attached to the backbone via an ester linkage. Thus, this compound is a triglyceride (also known as a triacylglycerol).

From our understanding of biochemistry, we know that triglycerides are a type of lipid, thus making this the correct answer.

The structure shown is not a protein or a nucleic acid, as both of these compounds contain nitrogen or phosphate as part of their molecular structure, respectively. Proteins are linked by a characteristic series of amino acids, each of which has a unique side chain group. Nucleic acids, on the other hand, contain a sugar-phosphate backbone connected by phosphodiester linkages, along with nitrogenous bases.

Furthermore, this structure is not a carbohydrate, as these structures generally have a carbon:hydrogen:oxygen ratio of .

3

Arachidonate is a precursor for all of the following except __________.

cholesterol

leukotrienes

thromboxanes

prostacyclin

prostaglandins

Explanation

Arachidonate is a precursor for many biologically important molecules. If acted on by lipoxygenases it can be converted to leukotrienes. If acted on by prostaglandin synthase and then subsequently by another (or several other) enzymes it can be converted to prostacyclin, prostaglandins, or thromboxanes. However, it is not a precursor for cholesterol.

4

From what type of molecule is vitamin A derived from?

Squalene

Glucose

Triacylglycerol

Cholesterol

Vitamin K

Explanation

An isoprene unit repeats many times to form molecules called terpenes. Squalene is a triterpine - made from six isoprene units. Vitamin A is known as a terpinoid because it is derived from squalene.

5

What hormone does this structure represent?

Cholesterol

Cholesterol

Testosterone

Progesterone

Estrogen

Luteinizing hormone

Explanation

The structure represents cholesterol. The hydroxyl group attached to the terminal cyclohexane and the 6-carbon chain on the opposite end are easily recognizable substituents.

6

Which of the following are true about phospholipids in structure?

I. Phospholipids consist of a polar group and nonpolar fatty acids, connected by glycerol.

II. Glycerophospholipids are a type of phospholipids and are composed of choline, phosphate, glycerol, and two fatty acids.

III. Sphingolipids, like sphingomyelin, are a type of phospholipids that have choline, phosphate, sphingosine groups and only one fatty acid.

I, II, and III

II and III

I and III

II only

I only

Explanation

Phospholipids have two fatty acid chains, with a length of 14-20 carbon atoms each, that attach to the carbons of the glycerol molecule. Examples of glycerophospholipids are phosphatidyl glycerol (PG). Examples of sphingolipids, like sphingomyelin, have choline, phosphate, sphingosine groups and only one fatty acid.

7

Organic peanut butter contains both saturated and unsaturated fats.

What is the difference between saturated and unsaturated fats?

Unsaturated fats contain double bonds and saturated fat do not

Unsaturated fats are lipids and saturated fats are carbohydrates

Unsaturated fats do not contain glycogen and saturated fats do

Unsaturated fats do not contain cholesterol and saturated fats do

Explanation

Unsaturated fats are said do be unsaturated because of their lack of saturation with hydrogen atoms, due to carbon's ability to make four bonds, and one or more carbons in the hydrocarbon tail of an unsaturated fatty acid contains a double bond to another carbon. Both unsaturated and saturated fats are lipids, but neither contain cholesterol nor glycogen.

8

Based on the structure of the molecule shown below, what is the most likely identification of this compound?

Vt biochem 11 27 15 cortisol

Cortisol

Epinephrine

Insulin

NADH

Methionine

Explanation

For this question, we're presented with the molecular structure of some unknown compound, and we're asked to identify which answer choice offers the most likely identity for this compound.

Since there's no way for us to know exactly what this molecule is (unless you have it memorized!), we'll need to look at each answer choice.

Insulin is a peptide hormone whose main function is to allow cells in the body to take up glucose from the blood.

Epinephrine is also a hormone, but in addition it can act as a neurotransmitter. One of epinephrine's main roles is in the fight-or-flight response, where it acts to mobilize the body's energy reserves in preparation for a demanding situation.

NADH is a cofactor involved in a variety of catabolic pathways, such as glycolysis. Its main role is to act as a carrier of high-energy electrons, which it can donate into the electron transport chain to produce cellular energy in the form of ATP.

Methionine is one of the twenty amino acids found in organisms. It thus acts as a key constituent in many proteins.

Cortisol is a steroid hormone, often called the "stress hormone." It plays a variety of roles in the body, some of which influence the body's metabolism of glucose (cortisol is a type of glucocorticoid hormone).

When looking at the structure given in the question stem, we can see that this is a pretty big molecule! While we don't need to have the exact structure of cholesterol memorized, we can recall that cholesterol is a big molecule that has multiple rings in its structure, just as this compound does. Thus, we can be reasonably sure that this compound is most likely a derivative of cholesterol. Many derivatives of cholesterol function as steroid hormones, which are largely hydrophobic molecules that are able to transverse cellular membranes. Since we know that cortisol is a steroid hormone, we can assume that this structure most likely represents cortisol.

9

What is the difference between linoleic and alpha-linolenic acid and what is their importance?

I. They are essential fatty acids.

II. Linoleic acid is unsaturated, has 2 double bonds and has an 18-carbon chain.

III. Alpha-linolenic acid is an eighteen-carbon molecule with 3 double bonds.

IV. Apha-linolenic acid is a seventeen-carbon molecule with 3 carbon double bonds.

I, II, and III

I, II, III, and IV

I and IV

II, III, and IV

II and IV

Explanation

Essential fatty acids cannot be produced by the body and need to be obtained thru diet. Linoleic acid is unsaturated, has 2 double bonds while alpha-linolenic acid has 3 double bonds. Both have a backbone structure of 18 carbons.

10

What is the name of the pictured fatty acid?

Arachidonic acid

Arachidonic acid

Linoleic acid

Oleic acid

Eicosapentaenoic acid

Palmitoleic acid

Explanation

The pictured structure represents arachidonic acid due to the 20-carbon carboxylic acid chain with characteristic unsaturated (double) bonds after carbons 5, 8, 11, and 14.

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