Ethanol Fermentation - Biochemistry

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Question

Multiple studies have shown that drinking lots of alcohol can lead to an increase in body fat.

From a biochemical perspective, what aspect of alcohol metabolism may suggest that it contributes to an increase in body fat?

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Answer

Fats are broken down into acetyl-CoA to be used for energy. However, large quantities of alcohol will produce large quantities of acetyl-CoA when metabolized. Acetyl-CoA can be converted into fatty acids when it is in excess. Then fatty acids can assemble into triglycerides and be stored as fat.

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