Understanding Viruses and Prions

Help Questions

AP Biology › Understanding Viruses and Prions

Questions 1 - 10
1

Which of the following is true of a bacteriophage?

Only its DNA enters the host cell

It is engulfed entirely by the host cell

It contains its own ribosomes

It can infect only plants or fungi

It always contain a circular DNA plasmid

Explanation

A bacteriophage is a virus which attacks bacteria and consists of a head, tail, and tail fibers all made of protein. The head contains genetic material (usually linear DNA) which is injected into the host bacterium upon infection. The protein parts do not enter the bacterium, and it does not have any ribosomes or organelles of its own.

2

Of the following types of molecules, which is always found in virions?

Protein

Lipid

DNA

RNA

Carbohydrate

Explanation

Virus particles, otherwise known as virions, always contain proteins. Whether they contain DNA or RNA depends solely upon the type of virion; different types of viruses will carry different types of nucleic acids. The capsids of virions contain proteins that surround the nucleic acids, whether it be DNA or RNA.

3

Which of the following describes the enzyme reverse transcriptase?

An RNA dependent DNA polymerase

An RNA dependent RNA polymerase

A DNA dependent RNA polymerase

A DNA dependent DNA polymerase

An RNA dependent protein polymerase

Explanation

Reverse transcriptase binds RNA and catalyzes the formation of a complementary DNA molecule. Since it needs an RNA template to work, this enzyme is RNA dependent. Since it forms a DNA molecule, this enzyme is a DNA polymerase. Recall the chemical difference between DNA and RNA - DNA lacks a hydroxide group at the 3' position of the ribose sugar, which makes it deoxyribose.

4

An important identifying difference between eukaryotic and prokaryotic cells is that __________.

eukaryotes have nuclei

prokaryotes are considerably larger and more complex

prokaryotes possess membrane-bound organelles; eukaryotes do not

All other answers are correct

prokaryotes have flagella; eukaryotes do not

Explanation

Eukaryotic cells have a nuclei; prokaryotic cells have no nuclei.

Eukaryotic cells are considerably larger and more complex. Eukaryotic cells possess membrane-bound organelles; prokaryotic cells, which are smaller and less complex, do not. Both eukaryotic and prokaryotic cells can have flagella, but not necessarily in all cases.

Note that ribosomes are not membrane-bound, and are found in both prokaryotes and eukaryotes.

5

Which of these is an example of a disease cause by a prion (misfolded protein)?

Bovine spongiform encephelopathy (mad cow disease)

HIV

Syphilis

Tuberculosis

Lupus

Explanation

The only disease out of these that is caused by a prion is mad cow disease, and is therefore the correct answer. HIV is caused by a virus, syphilis and tuberculosis by bacteria, and lupus is an autoimmune disorder.

6

Which of the following do retroviruses and bacteriophages have in common?

They can both enter the lysogenic cycle

They can both enter the lytic cycle

They both only infect prokaryotes

The both use reverse transcriptase

The both have only RNA genomes

Explanation

The lysogenic cycle occurs when a virus incorporates its DNA into the host genome. It stays inside the host genome, getting replicated along with the host until conditions are right when it excises itself and beings the process of hijacking the cell to make more virus. Both retroviruses and bacteriophages can undergo this process.

7

Viruses are not considered to be "alive" due to all of the following reasons except __________.

they do not contain DNA

they do not have cells

they can only reproduce within a host

they do not metabolize any kind of food

they do not respond to stimuli

Explanation

Some viruses have a DNA genome, while others use RNA. While DNA may be a crucial component to determining life, it cannot be used to differentiate viruses from living organisms because some viruses do carry their own DNA.

All viruses can be differentiated from living organisms because they do not "eat" or absorb nutrients, they do not have cells, they do not respond to stimuli, and they do not reproduce independently. All living organisms absorb nutrients, have cells, respond to stimuli, and are capable of reproduction, thus making viruses different.

8

Some vaccines are developed through attenuation of the actual viral organism. Attenuation occurs through giving the pathogen a nutrient rich environment to replicate in thus mutation occurs in virulence factors normally adapted by the virus for survival.

Which of these is a reason attenuation of the West Nile Virus for a suitable human vaccine has not occurred as yet?

All of these

A horse can develop the symptoms and an immune response to the West Nile Virus thus putting the virus back into competition to remain virulent

A chicken can develop the symptoms and an immune response to the West Nile Virus thus putting the virus back into competition to remain virulent

Human blood cell lines can are a target of the West Nile Virus thus putting the virus back into competition to remain virulent

Neuronal cell culture techniques have been unsuccessful in surviving replication of the virus

Explanation

The three main media of attenuating a virus are infecting birds, horses, or cultured cell lines. West Nile Virus is an interesting virus in that host and susceptible organisms happen to be birds, horses, and humans. This virus also does not seem to replicate in other animal reservoirs such as lizards. It does not replicate in mosquitos. Moreover, recent attempts to culture a neuronal cell line to replicate the virus have been unsuccessful due to the extended length of life cycle of neuronal cells.

9

Reverse transcriptase is __________.

produced by viruses and used by the cell to transcribe viral DNA that will be inserted into the genome of the infected cell

produced by the infected cell and used to inhibit viral transcription

produced by the infected cell and used to transcribe RNAs that will be translated by the cell into antibodies against viruses

produced by viruses and is used to inhibit normal DNA transcription

produced by viruses and used by the infected cell to transcribe viral RNAs that will be translated by the cell into viral proteins

Explanation

Reverse transcriptase is a viral enzyme used by some viruses to transcribe double-stranded DNA from their single-stranded RNA, which is the exact opposite of the normal transcription process of the cell. The double-stranded viral DNA is then able to integrate into the double-stranded DNA of the infected cell’s genome so that whenever the cell divides, all of its daughter cells will carry the viral DNA. This viral DNA can eventually be transcribed by the cell’s own enzymes to produce viral RNA. Some of the viral RNA will be translated into viral proteins, and new viruses will be assembled from these products.

10

Which of the following is characteristic of viruses?

A protein coat

Membrane bound organelles (e.g., Golgi apparatus)

Thick peptidoglycan cell wall

Cell wall made of chitin

Lipid bilayer outer membrane

Explanation

Viruses are unique organisms in that they have a relatively simple cell structure. They have an outer protein coat, which sets them apart from other organisms. Peptidoglycan is found in bacteria, lipid bilayer is found in eukaryotic cells, and chitin is found in fungi. Membrane-bound orangelles are found in more complex cells, such as eukaryotic cells, and are not unique to viruses.

Page 1 of 4
Return to subject