Drug Interactions and Biotransformation

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NCLEX-PN › Drug Interactions and Biotransformation

Questions 1 - 10
1

You are the nurse taking care of a patient being treated with metronidazole for a lower gastrointestinal infection. Which of the following instructions should you give the patient?

"Do not consume alcohol while taking this medication."

"Avoid operating heavy machinery while taking this medication."

"Do not eat spinach when taking this medication."

"Lie flat for 30 minutes after taking this medication."

"Do not take your cholesterol medication when taking this medication."

Explanation

The correct answer is "Do not consume alcohol while taking this medication."

In this question, what is really being tested is your knowledge of side effects/interactions with metronidazole. One of the major interactions to be aware of with metronidazole is that it can cause an unpleasant interaction when consumed with alcohol that is very similar to the symptoms that occur when one consumes alcohol while taking the alcohol deterrent, Antabuse. This reaction includes severe abdominal pain/cramping, nausea, vomiting, facial flushing, and headaches. Patients should avoid drinking alcohol while taking metronidazole and for three days after completing their course.

Eating spinach, lying flat for 30 minutes after taking metronidazole, taking cholesterol medication while taking metronidazole, and operating heavy machinery while taking metronidazole are inappropriate recommendations, as there are no known direct associations between metronidazole and spinach consumption, head elevation, cholesterol medications, or level of consciousness.

2

You are the nurse taking care of a patient being treated with metronidazole for a lower gastrointestinal infection. Which of the following instructions should you give the patient?

"Do not consume alcohol while taking this medication."

"Avoid operating heavy machinery while taking this medication."

"Do not eat spinach when taking this medication."

"Lie flat for 30 minutes after taking this medication."

"Do not take your cholesterol medication when taking this medication."

Explanation

The correct answer is "Do not consume alcohol while taking this medication."

In this question, what is really being tested is your knowledge of side effects/interactions with metronidazole. One of the major interactions to be aware of with metronidazole is that it can cause an unpleasant interaction when consumed with alcohol that is very similar to the symptoms that occur when one consumes alcohol while taking the alcohol deterrent, Antabuse. This reaction includes severe abdominal pain/cramping, nausea, vomiting, facial flushing, and headaches. Patients should avoid drinking alcohol while taking metronidazole and for three days after completing their course.

Eating spinach, lying flat for 30 minutes after taking metronidazole, taking cholesterol medication while taking metronidazole, and operating heavy machinery while taking metronidazole are inappropriate recommendations, as there are no known direct associations between metronidazole and spinach consumption, head elevation, cholesterol medications, or level of consciousness.

3

The nurse cares for a patient with a urinary tract infection (UTI). The patient has an allergy to penicillins. Which of the following medications is contraindicated for this patient’s illness?

Ceftriaxone

Streptomycin

Ciprofloxacin

Clindamycin

Sulfasalazine

Explanation

Patients with allergies to penicillins often have cross-allergies to cephalosporins. Cephalosporins such as ceftriaxone should be avoided by patients with these allergies. Patients with cephalosporin allergies should also avoid pencillins. Streptomycin, ciprofloxacin, clindamycin, and sulfasalazine may all treat UTIs but are not penicillins.

4

You are the nurse in a primary care clinic taking care of a 26-year old female with a urinary tract infection. You are counseling her about taking her antibiotic, cephalexin. You warn her that a common side effect is which of the following?

Diarrhea

Necrotizing skin rash

Headache

Hair loss

Pharyngitis

Explanation

The correct answer is "diarrhea." Diarrhea is a common side effect associated with antibiotic use, including cephalexin. This diarrhea is typically self-limited and resolves within the first day or two of administration. Sometimes patients are advised to take a probiotic or consume yogurt when starting a new antibiotic if they experienced diarrhea when starting antibiotics in the past.

Neither headaches, hair loss, pharyngitis, nor necrotizing skin rash are known common side effects of cephalexin use.

5

The nurse cares for a patient with a urinary tract infection (UTI). The patient has an allergy to penicillins. Which of the following medications is contraindicated for this patient’s illness?

Ceftriaxone

Streptomycin

Ciprofloxacin

Clindamycin

Sulfasalazine

Explanation

Patients with allergies to penicillins often have cross-allergies to cephalosporins. Cephalosporins such as ceftriaxone should be avoided by patients with these allergies. Patients with cephalosporin allergies should also avoid pencillins. Streptomycin, ciprofloxacin, clindamycin, and sulfasalazine may all treat UTIs but are not penicillins.

6

You are the nurse in a primary care clinic taking care of a 26-year old female with a urinary tract infection. You are counseling her about taking her antibiotic, cephalexin. You warn her that a common side effect is which of the following?

Diarrhea

Necrotizing skin rash

Headache

Hair loss

Pharyngitis

Explanation

The correct answer is "diarrhea." Diarrhea is a common side effect associated with antibiotic use, including cephalexin. This diarrhea is typically self-limited and resolves within the first day or two of administration. Sometimes patients are advised to take a probiotic or consume yogurt when starting a new antibiotic if they experienced diarrhea when starting antibiotics in the past.

Neither headaches, hair loss, pharyngitis, nor necrotizing skin rash are known common side effects of cephalexin use.

7

You are the nurse in a dermatology clinic taking care of a 22-year old female with severe nodular acne. She is going to start isotretinoin therapy after this appointment. She should be strictly advised to avoid which of the following?

Pregnancy

Eating bananas

Eating grain products

Drinking juices

Taking NSAID's

Explanation

The correct answer is "pregnancy." Patients initiating isotretinoin therapy should all be strictly advised to avoid becoming pregnant, and must absolutely not be started on isotretinoin therapy if they are actively pregnant. Isotretinoin is a potent teratogenic agent, and could cause devastating effects to a developing fetus, including but not limited to termination of the pregnancy. Any female patient who is going to start isotretinoin therapy must be tested for pregnancy immediately prior to therapy and repeatedly throughout treatment.

There is no known significant interaction between isotretinoin and NSAID use. Likewise, there is no reason why a patient on isotretinoin must avoid bananas, grains, or juices.

8

Which of the following is a symptom of digoxin toxicity?

Nausea, vomiting, and diarrhea

Rash

Tremor

Mood swings

Explanation

Nausea, vomiting, and diarrhea are common symptoms of digoxin toxicity. Other symptoms may include confusion, anorexia, irregular heartbeat, and palpitations. Tremors, mood swings, and rash are not generally seen with digoxin toxicity.

9

Which of the following is a symptom of digoxin toxicity?

Nausea, vomiting, and diarrhea

Rash

Tremor

Mood swings

Explanation

Nausea, vomiting, and diarrhea are common symptoms of digoxin toxicity. Other symptoms may include confusion, anorexia, irregular heartbeat, and palpitations. Tremors, mood swings, and rash are not generally seen with digoxin toxicity.

10

You are the nurse taking care of a patient with a history of schizophrenia, not on any medications, who is being admitted for disorganized thoughts, paranoid delusions, auditory hallucinations, and combative behavior. The physician orders a dose of haloperidol to be administered. Prior to giving the haloperidol, you suggest that which of the following be done?

Obtain an electrocardiogram (ECG)

Obtain a chest x-ray

Obtain a CT abdomen

Obtain a blood glucose level

Contact the authorities to detain the patient since he/she is being combative

Explanation

The correct answer is "Obtain an electrocardiogram (ECG)."

This question tests your knowledge of the major side effects of the first-generation anti-psychotic medication, haloperidol, also known as Haldol. Some of the major side effects of haloperidol include extrapyramidal symptoms, anticholinergic symptoms, blood pressure changes, and hypersomnolence.

In addition, haloperidol has the potential to prolong the QTc interval on an ECG. QTc prolongation can be particularly dangerous in patients who already have a prolonged QTc interval due to a pre-existing medical condition (e.g. Long QT Syndrome), or medications they are already taking. A prolonged QTc interval has the potential to progress on ECG to more dangerous arrhythmias including torsades de pointes and ventricular fibrillation/tachycardia, which can be fatal. Therefore, it is imperative to check a patient's QTc interval on an ECG prior to administering haloperidol to confirm that they do not already have a prolonged QTc interval.

While this patient's blood glucose is not necessarily going to be normal, that is not something that needs to be emergently checked prior to haloperidol administration.

There is no indication to obtain a chest x-ray or CT abdomen prior to haloperidol administration.

It would be inappropriate to contact the authorities to detain this acutely psychotic patient with schizophrenia, as the patient is already in the hospital and in the care of a psychiatric medical team. Further, even though the patient is combative, if necessary, the medical team is allowed to place the patient in restraints without the need for police intervention. There is no evidence that any members of the care team are in acute danger.

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