Drug Information>Source Selection Practice Test

A hospitalist asks about using low-dose ketamine infusions for refractory depression in a young adult after failure of multiple antidepressants. They want to understand evidence for efficacy, optimal dosing regimens, monitoring for adverse effects, and comparative safety versus esketamine. The indication is off-label for IV ketamine, and payer approval may depend on strength of evidence and guideline support. You need the highest-quality, most current data to critically appraise benefits and risks when labeling and tertiary compendia provide limited or inconsistent recommendations.

In the emergency department, a 6-year-old child (22 kg) is diagnosed with community-acquired pneumonia and discharged on oral amoxicillin-clavulanate. The pediatrician asks for a weight-based dose, maximum per dose, appropriate frequency, and guidance on selecting a suspension strength to avoid clavulanate overdose. The child has mild renal impairment and a history of poor palatability tolerance with prior antibiotics. You need a reliable, pediatric dosing resource that includes renal adjustments, product concentration options, and practical administration tips for caregivers. The team also asks about maximum daily clavulanate exposure.