Other Bone Concepts

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MCAT Biology › Other Bone Concepts

Questions 1 - 10
1

Which of the following is not a function of the skeletal system?

B-cell and T-cell development

Red blood cell formation

Fat storage

Mineral homeostasis

Explanation

The skeletal system is responsible for a variety of functions in the body. Long bones contain both red and yellow bone marrow, which are the sites for fat storage and hematopoeisis respectively. Bones are also responsible for the storage of calcium and phosphate, which can be released in order to maintain normal levels in the blood.

White blood cells are derived from stem cells in the bone marrow. B-cells continue to develop in the bone marrow, but T-cells develop in the thymus.

2

Osteocytes exchange nutrients through which structures in bone tissue?

Canaliculi

Lacunae

Lamellae

Haversian canals

Explanation

Osteocytes are differentiated osteoblasts that have become imbedded in hydroxyapatite bone matrix. The osteocytes are found in small gaps in bone matrix called lacunae and exchange nutrients with the blood using small canals called canaliculi. Lamellae are the concentric regions of osteocytes that are arranged around the central Haversian canal. The canal houses blood vessels and nerves to nourish and stimulate the osteocytes via the canaliculi.

3

Rickets is a condition typically found in immature mammals. The disease is characterized by a telltale "bowing" curvature to bones when pressure is placed upon them. Which of the following deficiencies in bone would result in rickets-like symptoms?

Calcium

Collagen

Red bone marrow

Yellow bone marrow

Explanation

When it comes to the strength and resilience of bone, both collagen and calcium play important roles. Collagen provides bones with great tensile strength, and calcium (usually in the form of hydroxyapatite) provides bones with great compressive strength. In the event of a calcium deficiency, weight placed on bones would cause them to bend irregularly, resulting in the characteristic bending of bones found with rickets.

A deficiency in collagen would cause damage to the bone during extension or stretching forces. Bone marrow does not play an important structural role, and is more important for bone function.

4

Slightly soluble calcium salts, such as calcium hydrogen phosphate, are found in the matrices of bone. What do these salts primarily contribute to the functions of the skeletal system?

Mineral storage

Energy storage

Movement

Blood cell production

Explanation

Bone matrices store these slightly soluble calcium salts so that they can be released into the bloodstream in times of low blood calcium levels. As a result, these salts are an example of how the skeletal system provides mineral storage for the body.

Movement and bone cell production are also primary functions of the skeletal system, but are not linked to calcium salts. Energy storage is linked to the fats stored in the yellow marrow of the bone.

5

Several ligaments act together to join the femur and tibia, forming the knee joint. The complexity of the knee makes it prone to injury. A direct blow to the anterior upper tibia can damage the posterior cruciate ligament, while a blow to the posterior upper tibia can damage the anterior cruciate ligament. The collateral ligaments are located medial and lateral to the joint, and can be damaged from blunt trauma to the sides of the knee.

A skier falls, twists his right knee, and experiences excruciating pain at the inner side of the knee. Upon consulting a physician, the skier learns that he has torn one of the ligaments in his knee. The location of pain and cause of injury are most consistent with what kind of ligament tear?

Medial collateral ligament (MCL)

Anterior cruciate ligament (ACL)

Posterior cruciate ligament (PCL)

Lateral collateral ligament (LCL)

Explanation

Skiers and American football players are prone to medial collateral ligament (MCL) injuries. The MCL is a major ligament of the knee that resides on the inner (medial) side of the knee. The MCL is connected to the tibia and femur, as well as the meniscus and anterior cruciate ligament, making compound injuries common.

The anterior cruciate ligament resides at the front (anterior) side of the knee, while the posterior cruciate ligament resides to the back (posterior) of the knee. The medial meniscus is a fibrocollagen band that is fused with the MCL.

6

The patella is attached to the tibia by a thick band of fibrous tissue referred to as a __________.

ligament

tendon

joint

muscle

Explanation

Ligaments connect a bone to another bone, while tendons attach a muscle to a bone. Since two bones are being connected by the fibrous band of tissue in question, we can confirm that it is a ligament.

Muscle does not actually form a functional connection; rather, muscle will transition to a tendon, which will connect to a bone. Joints are comprised of several different structures and tissues, and are the articulations between two bones.

7

Rickets is a disorder that is commonly caused by a vitamin D deficiency. The disorder results in bones that can bend and cause deformities.

Based on this information, what is the effect of rickets on the bones of a patient?

There is a decrease of calcium in the bones

There is a decrease of collagen in the bones

There are not enough osteoblasts in order to create bone matrix

There is too much calcium deposited in the bones

Explanation

Vitamin D aids in calcium absorption in the small intestine. In the absence of vitamin D, inadequate absorption causes a deficiency of calcium in the body. Without calcium, the bones will not have adequate tensile strength, which can cause a bowing effect in bones that support weight, such as the femurs. Collagen in the bones is associated with resistance to compression, rather than tensile strength, and is not linked to vitamin D.

8

Which of the follwoing is not an important function of bone?

Regulation of pH through hydration

Regulation of ion concentration

Organ and nerve protection

Muscular contraction

Explanation

The skeleton plays a role in musclular contraction in that it serves as an anchor and provides leverage against which muscles can exert force. It also serves as protection and support for soft tissues. Bones also maintain certain ion concentrations. The correct answer choice is the regulation of pH through hydration, which is not a function of the skeletal system.

9

Bone hardness is primarily due to which of the following?

Hydroxyapatite (composed of calcium and phosphorus) and collagen

Hydroxyapatite (composed of calcium and bicarbonate) and collagen

Hydroxyapatite (composed of glycosaminoglycans and collagen) and bicarbonate

Glycosaminoglycans and collagen

Explanation

There are organic (collagen) and inorganic (hydroxyapatite) components of the bone that contribute to its characteristic hardness. The key here is knowing the composition of hydroxypatite, which is primarily constructed of calcium and phosphorus.

10

Which of the following is not a main mineral component of human bone?

Potassium

Calcium

Phosphate

Hydroxyl groups

Explanation

Bone consists of calcium-phosphate crystals, known as hydroxyapatite, in a collagen matrix. The molecular formula for hydroxyapatite is . Collagen's structure depends on hydroxylysine and hydroxyproline for stability. Potassium is not required in bone.

While these specific formulas are not generally tested knowledge, it is important to know what molecules may influence bone composition and growth.

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