Glands

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MCAT Biology › Glands

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1

A patient is admitted to the hospital after a traumatic injury to her adrenal cortex. Which of the following hormones is most likely to be present at normal levels?

Antidiuretic hormone (ADH)

Adrenocorticotropic hormone (ACTH)

Cortisol

Aldosterone

Corticotropin-releasing hormone (CRH)

Explanation

Of all the hormones listed, antidiuretic hormone (ADH) is the only one that neither acts on, nor is released by, the adrenal cortex. ADH is released from the posterior pituitary and causes the kidneys to retain more water.

Aldosterone (a mineralcorticoid) and cortisol (a glucocorticoid) are both incorrect choices because they are released by the adrenal cortex and would be greatly affected by trauma to that area. ACTH is released by the anterior pituitary and acts to stimulate the adrenal cortex; these hormones act as part of a negative feedback chain, so damage to the target area would temporarily cause more ACTH to be produced. The same goes for CRH, which is released by the hypothalamus and stimulates secretion of ACTH.

2

A patient is admitted to the hospital after a traumatic injury to her adrenal cortex. Which of the following hormones is most likely to be present at normal levels?

Antidiuretic hormone (ADH)

Adrenocorticotropic hormone (ACTH)

Cortisol

Aldosterone

Corticotropin-releasing hormone (CRH)

Explanation

Of all the hormones listed, antidiuretic hormone (ADH) is the only one that neither acts on, nor is released by, the adrenal cortex. ADH is released from the posterior pituitary and causes the kidneys to retain more water.

Aldosterone (a mineralcorticoid) and cortisol (a glucocorticoid) are both incorrect choices because they are released by the adrenal cortex and would be greatly affected by trauma to that area. ACTH is released by the anterior pituitary and acts to stimulate the adrenal cortex; these hormones act as part of a negative feedback chain, so damage to the target area would temporarily cause more ACTH to be produced. The same goes for CRH, which is released by the hypothalamus and stimulates secretion of ACTH.

3

Which hormone is secreted from the anterior pituitary?

Follicle-stimulating hormone

Somatostatin

Oxytocin

Vasopressin

Explanation

The pituitary gland is comprised for the anterior and posterior pituitary. The anterior pituitary arises from the oral ectoderm, while the posterior pituitary arises from the neuroectoderm. Hormones are secreted from the anterior pituitary in response to stress or to promote milk production, growth, or reproduction. Follicle-stimulating hormone (FSH) is required for growth of the reproductive system.

The posterior pituitary is responsible for production and secretion of neurohypophysical hormones, including oxytocin and vasopressin. Somatostatin is produced from within the digestive system, and signals to the anterior pituitary to inhibit growth hormone secretion.

The hormones of the anterior pituitary can be remembered by using the pneumonic "FLAT PEG." The anterior pituitary secretes follicle-stimulating hormone, luteinizing hormone, adrenocorticotropic hormone, thyroid-stimulating hormone, prolactin, endorphins, and growth hormone.

4

The adrenal medulla is responsible for secreting which hormone?

Epinephrine

Aldosterone

Cortisol

Corticotropin-releasing hormone

Explanation

The adrenal medulla, derived from neural crest cells, is responsible for making and releasing epinephrine and norepinephrine. Epinephrine and norepinephrine are responsible for increasing heart rate and activating the sympathetic nervous system when released.

In contrast, the adrenal cortex is derived from mesoderm and releases steroid hormones like aldosterone and cortisol. Corticotropin-releasing hormone is made by the parvocellular neurons of the hypothalamus.

5

The adrenal medulla is responsible for secreting which of the following hormones?

Epinephrine

Adrenocorticotropic hormone

Growth hormone

Thyroid-stimulating hormone

Explanation

Epinephrine and norepinephrine are released by the neuroendocrine cells of the adrenal medulla. In times of stress and sympathetic nervous system activation, the adrenal medulla will release epinephrine to cause blood vessel constriction. These hormones allow for the "fight-or-flight" response.

In contrast, the adrenal cortex will secrete cortisol and other mineralcorticoids in response to long-term stress. These hormones are not involved in the fight-or-flight response, and rather serve to prepare the body to endure prolonged harsh conditions, such as dehydration, starvation, and extreme temperatures. Adrenocorticotropic hormone is released from the anterior pituitary to stimulate the adrenal cortex.

Growth hormone and thyroid-stimulating hormone do not interact with the adrenal gland.

6

The adrenal medulla is responsible for secreting which of the following hormones?

Epinephrine

Adrenocorticotropic hormone

Growth hormone

Thyroid-stimulating hormone

Explanation

Epinephrine and norepinephrine are released by the neuroendocrine cells of the adrenal medulla. In times of stress and sympathetic nervous system activation, the adrenal medulla will release epinephrine to cause blood vessel constriction. These hormones allow for the "fight-or-flight" response.

In contrast, the adrenal cortex will secrete cortisol and other mineralcorticoids in response to long-term stress. These hormones are not involved in the fight-or-flight response, and rather serve to prepare the body to endure prolonged harsh conditions, such as dehydration, starvation, and extreme temperatures. Adrenocorticotropic hormone is released from the anterior pituitary to stimulate the adrenal cortex.

Growth hormone and thyroid-stimulating hormone do not interact with the adrenal gland.

7

Which hormone is secreted from the anterior pituitary?

Follicle-stimulating hormone

Somatostatin

Oxytocin

Vasopressin

Explanation

The pituitary gland is comprised for the anterior and posterior pituitary. The anterior pituitary arises from the oral ectoderm, while the posterior pituitary arises from the neuroectoderm. Hormones are secreted from the anterior pituitary in response to stress or to promote milk production, growth, or reproduction. Follicle-stimulating hormone (FSH) is required for growth of the reproductive system.

The posterior pituitary is responsible for production and secretion of neurohypophysical hormones, including oxytocin and vasopressin. Somatostatin is produced from within the digestive system, and signals to the anterior pituitary to inhibit growth hormone secretion.

The hormones of the anterior pituitary can be remembered by using the pneumonic "FLAT PEG." The anterior pituitary secretes follicle-stimulating hormone, luteinizing hormone, adrenocorticotropic hormone, thyroid-stimulating hormone, prolactin, endorphins, and growth hormone.

8

The adrenal medulla is responsible for secreting which hormone?

Epinephrine

Aldosterone

Cortisol

Corticotropin-releasing hormone

Explanation

The adrenal medulla, derived from neural crest cells, is responsible for making and releasing epinephrine and norepinephrine. Epinephrine and norepinephrine are responsible for increasing heart rate and activating the sympathetic nervous system when released.

In contrast, the adrenal cortex is derived from mesoderm and releases steroid hormones like aldosterone and cortisol. Corticotropin-releasing hormone is made by the parvocellular neurons of the hypothalamus.

9

Which of the following correctly matches a gland to the function of a hormone it releases?

Posterior pituitary releases a hormone to cause water retention in kidneys

Posterior pituitary releases a hormone to cause follicle development

Anterior pituitary releases a hormone to cause uterine contractions

Parathyroid releases a hormone to reduce blood calcium

Adrenal cortex releases a hormone to raise blood glucose

Explanation

The posterior pituitary releases antidiuretic hormone (vasopressin), which causes water retention in the kidneys, making this the correct answer.

Follicle-stimulating hormone causes follicle development, and is released from the anterior (not the posterior) pituitary.

Oxytocin causes uterine contractions, and is released from the posterior (not the anterior) pituitary.

Calcitonin helps to reduce blood calcium, and is released from the thyroid. Parathyroid hormone acts counter to calcitonin, and increases blood calcium.

Glucagon helps to increase blood glucose levels by stimulating glycogen break-down, and is released from the pancreas (not the adrenal gland).

10

Which of the following hormones is not produced by the anterior pituitary gland?

Oxytocin

Growth hormone

Follicle-stimulating hormone

Prolactin

Explanation

Oxytocin is produced by the hypothalamus and stored in the posterior pituitary gland. Upon stimulation, oxytocin is released from the posterior pituitary to cause lactation and uterine contractions during pregnancy, though it has also been linked to some social phenomena.

Growth hormone, follicle-stimulating hormone, and prolactin are produced and secreted from the anterior pituitary gland. Growth hormone promotes bone elongation and cell division. Follicle-stimulating hormone works to regulate the menstrual cycle. Prolactin stimulates milk production, while oxytocin stimulates the actual act of lactation.

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