GRE Subject Test: Biochemistry, Cell, and Molecular Biology › Help with Linkage
What does it mean to say that two genes are linked?
The genes almost always segregate together during meiosis
The genes share a promoter
The genes code for the same mRNA
The genes overlap one another
Genetic linkages are determined by frequencies of recombination. These are measures of how often chromosomal crossovers will take place between two genes. The closer the loci of the two genes are on a chromosome, the less likely a crossover event will separate the two genes. If the recombination frequencies are sufficiently low, the genes are considered to be linked.
Genetic linkage has nothing to do with genes coding for the same mRNA, sharing a promoter, or overlapping one another. Linked genes still code for distinctly separate traits/proteins and have different loci (don't overlap).