Biochemistry › Sphingolipids
The myelin sheaths of neurons typically contain large quantities of __________.
sphingolipids
cholesterol
waxes
triacylglycerols
Myelin sheaths surround nerve cell axons and are essential for proper nervous system function. They act as an electrically insulating layer and enable better propagation of action potentials. Sphingomyelin is a type of sphingolipid found in the myelin sheaths of animal cell membranes.
Lysosomal storage diseases occur when mutations cause defects in which of the following?
Sphingolipid degradation enzymes
Sphingolipid biosynthesis enzymes
Lysosome formation
Formation of N-acetylgalactosamine derivatives
Lysosome transformation
Lysosomal storage diseases occur when mutations cause defects in sphingolipid degradation enzymes. Simply put, the key word is "degradation," which indicates the presence of a disease. No other answer choice has a key word that indicates the presence of a disease.
Which of the following is amphipathic, polar, and are formed by long-chain sphingolipids?
Sphingosine
Palmitoyl-CoA
Sphingomyelin
Glucosamine
Ceramide
Glucosamine contributes to the structure of glycosylphosphatidylinositol (GPI). Ceramide is the precursor to sphingomyelin, sphingosine is hydrolyzed to form ceramide.
Which of the following is the smallest sphingolipid in terms of molecular mass?
Sphingomyelin
Cerebroside
Ganglioside
Ceramide
All four of these sphingolipids differ only in the functional groups attached to the sphingosine. Ceramide has a fatty acid group; cerebroside has a monosaccharide group; ganglioside has a polysaccharide group; sphingomyelin has a phosphatidylcholine or phosphoethanolamine group. In terms of molecular mass, phosphatyidylcholine or phosphoethanolamine are the smallest as well as the least massive functional group, making sphingomyelin the sphingolipid with the smallest molecular mass.
Ceramide is a precursor to which of the following?
Sphingomyelin and glycosphingolipids
Glycoshingolipids only
Sphingomyelin only
Sphingolipids only
Sphingosine
Ceramide is formed by sphingosine. Sphingosine is formed by a long chain of sphingolipids. Both sphingomyelin and glycosphingolipids are formed from ceramide.