Sphingolipids

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Biochemistry › Sphingolipids

Questions 1 - 5
1

The myelin sheaths of neurons typically contain large quantities of __________.

sphingolipids

cholesterol

waxes

triacylglycerols

Explanation

Myelin sheaths surround nerve cell axons and are essential for proper nervous system function. They act as an electrically insulating layer and enable better propagation of action potentials. Sphingomyelin is a type of sphingolipid found in the myelin sheaths of animal cell membranes.

2

Lysosomal storage diseases occur when mutations cause defects in which of the following?

Sphingolipid degradation enzymes

Sphingolipid biosynthesis enzymes

Lysosome formation

Formation of N-acetylgalactosamine derivatives

Lysosome transformation

Explanation

Lysosomal storage diseases occur when mutations cause defects in sphingolipid degradation enzymes. Simply put, the key word is "degradation," which indicates the presence of a disease. No other answer choice has a key word that indicates the presence of a disease.

3

Which of the following is amphipathic, polar, and are formed by long-chain sphingolipids?

Sphingosine

Palmitoyl-CoA

Sphingomyelin

Glucosamine

Ceramide

Explanation

Glucosamine contributes to the structure of glycosylphosphatidylinositol (GPI). Ceramide is the precursor to sphingomyelin, sphingosine is hydrolyzed to form ceramide.

4

Which of the following is the smallest sphingolipid in terms of molecular mass?

Sphingomyelin

Cerebroside

Ganglioside

Ceramide

Explanation

All four of these sphingolipids differ only in the functional groups attached to the sphingosine. Ceramide has a fatty acid group; cerebroside has a monosaccharide group; ganglioside has a polysaccharide group; sphingomyelin has a phosphatidylcholine or phosphoethanolamine group. In terms of molecular mass, phosphatyidylcholine or phosphoethanolamine are the smallest as well as the least massive functional group, making sphingomyelin the sphingolipid with the smallest molecular mass.

5

Ceramide is a precursor to which of the following?

Sphingomyelin and glycosphingolipids

Glycoshingolipids only

Sphingomyelin only

Sphingolipids only

Sphingosine

Explanation

Ceramide is formed by sphingosine. Sphingosine is formed by a long chain of sphingolipids. Both sphingomyelin and glycosphingolipids are formed from ceramide.

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