Embryonic cleavage is the division of cells without cell growth. Once an ovum is fertilized by a sperm cell, it is called a zygote. The zygote undergoes multiple rapid cell cycles (rounds of mitosis) without significant growth, producing a dense cluster of cells that is the same size as the original zygote. This process is called cleavage.

This question asks how the response of muscle of an MG patient would differ from the response of muscle of a healthy person to stimulation by a neuron. This is a question that can stand alone from the passage; no information or data from the passage is required to answer the question.

When acetylcholine binds its receptor on a muscle cell it produces a depolarization wave that opens channels in the plasma membrane and sarcoplasmic reticulum. As a result, flows out into the sarcoplasm where it stimulates the interaction of actin and myosin and the sliding of the filaments. Since a patient with myasthenia gravis will have a reduced number of functional acetylcholine receptors, the depolarization signal will be smaller, less will be released and fewer actin-myosin cross bridges will form. This sequence of events will result in the weaker contraction in the muscle of the myasthenia gravis patient. The number of troponin molecules bound to tropomyosin does not change during contraction. Troponin is bound to tropomyosin when the muscle is at rest. When is released from the sarcoplasmic reticulum, it binds to troponin and causes it to twist the tropomyosin enough to expose the actin myosin binding sites. Since troponin is bound to tropomyosin at rest and during contraction, there shouldn’t be any difference in the number of troponin-tropomyosin interactions in patients with myasthenia gravis as compared with normal individuals.

The gastrointestinal, or digestive, system is primarily designed to break down (catabolize) nutrients and absorb them into the blood for use by the body. Digestion of nutrients by stomach and pancreatic enzymes allows for their absorption in the small intestine. The large intestine is responsible for water absorption.

Filtration occurs in three primary areas in the body: the kidney, the liver, and the spleen/lymph nodes. The kidney is part of the excretory system, in which fluids are filtered from the blood to remove solute waste from the body. The liver filters the blood in circulation, and is responsible for removing toxins that may have been absorbed during digestion. It is not, however, part of the gastrointestinal tract. The spleen and lymph nodes filter the interstitial fluid to screen for antigens and pathogens.

The liver is primarily responsible for the detoxification of the blood.

All other listed options are the primary roles of the lymphatic system. Digested fats are emulsified in the small intestine, then transported via lymph (rather than blood). They enter the blood stream through the subclavian vein. The lymph also contains a large number of lymphocytes, or white blood cells, which can screen for microbes. Excess interstitial fluid is transferred to the lymph via leaky capillaries. The thymus, a primary lymphoid organ, is responsible for T-cell maturation.

If Mendel's law of independent assortment applied to this case, we would expect to see a normal 9:3:3:1 phenotypic ratio of offspring. Also, we know that the recessive phenotypes are not lethal because we are told that approximately 25% of the progeny were homozygous recessive for both traits. The most likely explanation is that the genes are linked (located very closely on the same chromosome) and, thus, segregate together. Even if the insects had high rates of recombination it would not affect these genes that are, according to the offspring ratios, completely linked.

As we are told in the passage, phase I metabolism occurs by the transfer of electrons, commonly called an oxidation-reduction reaction. Phase I metabolism in the liver serves primarily to oxidize endogenous and exogenous molecules by passing electrons from a substrate to iron, and finally to oxygen. These oxidation reactions are carried out by the cytochrome P450 system and allow metabolites to become more soluble in urine for excretion. The other reactions listed are carried out by various transferases during phase II metabolism in the liver.

Skeletal muscle is under voluntary control, and are innervated by the somatic nervous system. Skeletal muscle is responsible for skeletal movement, such as swinging the arms or lifting the legs.

Cardiac and smooth muscle are under the control of the autonomic nervous system. Cardiac muscle contracts the heart autonomously, without additional neuronal input.

In order to stimulate digestion in the stomach G cells secrete gastrin, which stimulates parietal cells. Pepsinogen is released by chief cells. The parietal cells release hydrochloric acid into the stomach lumen. The lowered acidity cleaves pepsinogen and creates pepsin, which begins to degrade proteins.

Mucous cells have the nondigestive role of lubricating the stomach lumen and protecting the stomach epithelium from degradation by the highly acidic gastric juices.

There are four major types of connections between cells that facilitate intercellular communication and interaction: gap junctions, desmosomes, adherens junctions, and tight junctions.

Gap junctions are tunnels between cells, formed by perforations in the plasma membrane, that allow ions and molecules to pass between cells. Desmosomes connect the cytoskeletons of adjacent cells, assisting in force transduction. Adherens junctions use specialized proteins called cadherins and catenins to create a strong adhesion between adjacent cells. They are similar to desmosomes, but have different molecular components. Finally, tight junctions, as the name suggests, are sealed connections that do not permit exchange of fluid between cells. The question states that there is no exchange of water and ions between the cells; therefore, the connection between the cells must be a tight junction.

Plasmodesmata are similar to gap junctions, but they are only found in plant cell walls. They connect adjacent plant cells and facilitate intercellular communication and movement of nutrients between cells.

Fine touch, vibration, proprioception and 2 points discrimination all utilizes the dorsal column pathway. The upper region utilizes the cuneate fasciculus in the spinal cord while the lower region depends on the gracile fasciculus. According to the passage, these sensations are of the rapid pathway whereas other sensations such as pain is not as fast. The dorsal column pathway is heavily myelinated while the pain pathway is not as myelinated.