Endocrine Physiology

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Anatomy › Endocrine Physiology

Questions 1 - 10
1

Which of the following is not a role of insulin?

Increases glycogenolysis

Increases glycogen synthesis and storage

Increases triglyceride storage

Increases protein synthesis in muscles

Increases cellular uptake of potassium

Explanation

Insulin is made in the beta cells of the pancreas in response to ATP from glucose metabolism. Insulin inhibits glucagon release by alpha cells of the pancreas in a negative feedback mechanism to maintain constant blood glucose levels.

Insulin has several anabolic effects, including increased glucose transport in skeletal muscle and adipose tissue, increased glycogen synthesis and storage, increased triglyceride storage, increased protein synthesis in muscles, and increased cellular uptake of potassium and amino acids.

Glycogen is made by pancreatic alpha cells and is secreted in response to hypoglycemia, resulting in glycogenolysis and gluconeogenesis to increase circulating blood glucose levels.

2

Which of the following is not a role of insulin?

Increases glycogenolysis

Increases glycogen synthesis and storage

Increases triglyceride storage

Increases protein synthesis in muscles

Increases cellular uptake of potassium

Explanation

Insulin is made in the beta cells of the pancreas in response to ATP from glucose metabolism. Insulin inhibits glucagon release by alpha cells of the pancreas in a negative feedback mechanism to maintain constant blood glucose levels.

Insulin has several anabolic effects, including increased glucose transport in skeletal muscle and adipose tissue, increased glycogen synthesis and storage, increased triglyceride storage, increased protein synthesis in muscles, and increased cellular uptake of potassium and amino acids.

Glycogen is made by pancreatic alpha cells and is secreted in response to hypoglycemia, resulting in glycogenolysis and gluconeogenesis to increase circulating blood glucose levels.

3

What hormones, secreted by the adrenal medulla, facilitate the fight or flight response?

Epinephrine and norepinephrine

Triiodothyronine and thyroxine

Estrogen and progesterone

Gastrin and secretin

Explanation

The adrenal medulla produces epinephrine and norepinephrine, which cause the fight or flight response. The thyroid gland produces triiodothryonine and thyroxine, which are used for metabolism, growth, and development. The ovaries and placenta produce estrogen and progesterone, which are used for fetal/maternal development and egg production. Lastly, the stomach and small intestines produce gastrin and secretin, which are used to assist digestion and nutrient absorption.

4

Which of the following is not a role of insulin?

Increases glycogenolysis

Increases glycogen synthesis and storage

Increases triglyceride storage

Increases protein synthesis in muscles

Increases cellular uptake of potassium

Explanation

Insulin is made in the beta cells of the pancreas in response to ATP from glucose metabolism. Insulin inhibits glucagon release by alpha cells of the pancreas in a negative feedback mechanism to maintain constant blood glucose levels.

Insulin has several anabolic effects, including increased glucose transport in skeletal muscle and adipose tissue, increased glycogen synthesis and storage, increased triglyceride storage, increased protein synthesis in muscles, and increased cellular uptake of potassium and amino acids.

Glycogen is made by pancreatic alpha cells and is secreted in response to hypoglycemia, resulting in glycogenolysis and gluconeogenesis to increase circulating blood glucose levels.

5

What hormones, secreted by the adrenal medulla, facilitate the fight or flight response?

Epinephrine and norepinephrine

Triiodothyronine and thyroxine

Estrogen and progesterone

Gastrin and secretin

Explanation

The adrenal medulla produces epinephrine and norepinephrine, which cause the fight or flight response. The thyroid gland produces triiodothryonine and thyroxine, which are used for metabolism, growth, and development. The ovaries and placenta produce estrogen and progesterone, which are used for fetal/maternal development and egg production. Lastly, the stomach and small intestines produce gastrin and secretin, which are used to assist digestion and nutrient absorption.

6

What hormones, secreted by the adrenal medulla, facilitate the fight or flight response?

Epinephrine and norepinephrine

Triiodothyronine and thyroxine

Estrogen and progesterone

Gastrin and secretin

Explanation

The adrenal medulla produces epinephrine and norepinephrine, which cause the fight or flight response. The thyroid gland produces triiodothryonine and thyroxine, which are used for metabolism, growth, and development. The ovaries and placenta produce estrogen and progesterone, which are used for fetal/maternal development and egg production. Lastly, the stomach and small intestines produce gastrin and secretin, which are used to assist digestion and nutrient absorption.

7

Antidiuretic hormone is produced by the __________ and released by the __________.

hypothalamus . . . neurohypophysis (posterior pituitary)

neurohypophysis (posterior pituitary) . . . neurohypophysis (posterior pituitary)

hypothalamus . . . adenohypophysis (anterior pituitary)

adenohypophysis (anterior pituitary) . . . adenohypophysis (anterior pituitary)

neurohypophysis (posterior pituitary) . . . adrenal medulla

Explanation

Antidiuretic hormone (ADH) is a hormone that is produced in the hypothalamus and travels down nerve ending from the hypothalamus to be released from the posterior pituitary (neurohypophysis). ADH is the hormone that is responsible for reabsorbing water back into the blood stream at the level of the kidney.

8

What hormone, released by the liver, increases blood pressure?

Angiotensinogen

Cortisol

Oxytocin

Vitamin D3

Explanation

The liver secretes angiotensinogen and insulin-like growth factors. Only angiotensinogen is responsible for increasing blood pressure by acting on blood vessels. Cortisol is released by the adrenal cortex, oxytocin is released by the posterior pituitary, and vitamin D3 is found being activated in the skin. Angiotensinogen is a zymogen that is converted into angiotensin I by renin (secreted by the kidney). Then angiotensin converting enzyme (ACE) converts angiotensin I into angiotensin II, which is a potent vasoconstrictor. Angiotensin II also promotes the release of aldosterone from the adrenal cortex, which increases sodium reabsorption. Lastly, antidiuretic hormone (ADH) is released from the posterior pituitary to act on the distal convoluted tubule and the collecting duct to increase the permeability of water via upregulation of aquaporins. Together, these hormones act to increase blood pressure.

9

A baseball player is taking exogenous steroids for 1 year. Which of the following organs will be suppressed?

Adrenal glands

Kidneys

Heart

Liver

Lungs

Explanation

Steroids, when taken exogenously, diminish the production of steroids in the body. This can lead to atrophy of the adrenal glands (responsible for producing cortisol-stress steroid hormone). Thus, when patients are taking steroids for whatever reasons (sports, chemo, infection and etc) it is important for the steroids to be tapered off and not removed immediately since the body needs time to begin to reproduce the hormone again.

10

Within the adrenal glands, where are chromaffin cells located?

Adrenal medulla

Zona reticularis

Zona fasciculata

Zona glomerulosa

Adrenal capsule

Explanation

Chromaffin cells are found in the adrenal medulla (adrenal glands are located above the kidneys.) Chromaffin cells are regulated by preganglionic sympathetic fibers and release catecholamines, epinephrine (adrenaline) and norepinephrine (noradrenaline) into systemic circulation. The secreted epinephrine and norepinephrine play an important role in the "fight or flight" response elicited by the sympathetic nervous system. The zona glomerulosa is responsible for secreting aldosterone, the zona fasciculata is responsible for secreting cortisol (and a small amount of androgens) and the zona reticularis is primarily responsible for secreting androgens.

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