Hematologic malignancies Practice Test

A 70-year-old woman presents with headaches, blurred vision, and recurrent nosebleeds. Physical examination reveals mild hepatosplenomegaly. Laboratory evaluation shows a normocytic anemia and a large M-spike on serum protein electrophoresis. Immunofixation identifies the monoclonal protein as IgM. The serum viscosity is found to be significantly elevated.

A 50-year-old woman presents for a follow-up visit. She was treated for Stage IIB Hodgkin lymphoma 25 years ago with chemotherapy and mantle field radiation therapy. She is currently asymptomatic. Her blood pressure is 130/80 mm Hg and her BMI is 24 kg/m². She does not smoke.