Coagulation & bleeding disorders Practice Test

A 72-year-old man on apixaban for stroke prevention in the setting of atrial fibrillation is involved in a high-speed motor vehicle collision. He has multiple traumatic injuries, including a splenic laceration with active extravasation on CT scan. He is hypotensive and tachycardic. Which of the following is the most appropriate agent to reverse his anticoagulation?

A 67-year-old man with end-stage renal disease presents with persistent oozing from his hemodialysis arteriovenous fistula site after a recent session. His platelet count is 175,000/µL, prothrombin time is normal, and activated partial thromboplastin time is normal. The bleeding is difficult to control with local pressure.