Pentose Phosphate Pathway And Redox Balance Practice Test

A 24-year-old man of Mediterranean descent presents to the emergency department with a 2-day history of fatigue, jaundice, and dark-colored urine. He was diagnosed with a urinary tract infection 4 days ago and was started on trimethoprim-sulfamethoxazole. He has no other significant past medical history. Physical examination reveals scleral icterus and pallor. Laboratory studies show a hemoglobin of 8.9 g/dL (normal: 13.5-17.5 g/dL), an elevated reticulocyte count, and increased indirect bilirubin.

A 30-year-old African American man is prescribed primaquine as prophylaxis before traveling to a malaria-endemic region. Ten days later, he develops pallor, scleral icterus, and back pain. A peripheral blood smear is prepared and stained with crystal violet.