Immunodeficiency Disorders Practice Test

A 5-year-old child living in a refugee camp is diagnosed with severe protein-energy malnutrition (kwashiorkor). The child has concurrent measles infection with complications of pneumonia and severe diarrhea. Physical examination reveals significant edema, skin lesions, and hair discoloration.

A 1-year-old boy presents with opportunistic infections and failure to thrive. Flow cytometry shows normal numbers of CD4+ and CD8+ T-cells in the peripheral blood. However, when his lymphocytes are cultured with phytohemagglutinin (a T-cell mitogen), they fail to proliferate. B-cell and NK-cell numbers and function are normal.