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Cancer Biology And Neoplasia Practice Test
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Q1
A 62-year-old man is found to have a 4-cm mass in his kidney on an abdominal CT scan performed for an unrelated reason. A biopsy confirms clear cell renal cell carcinoma. The pathologist notes that the tumor is highly vascular. This type of tumor is often associated with mutations in the VHL gene.
The prominent neovascularization seen in this patient's tumor is primarily driven by the overexpression of which of the following factors, which is normally degraded in a VHL-dependent manner?
The prominent neovascularization seen in this patient's tumor is primarily driven by the overexpression of which of the following factors, which is normally degraded in a VHL-dependent manner?