Indications And Scheduling Practice Test

A 49-year-old male (77 kg) is initiating therapy for gout flare prophylaxis while starting urate-lowering therapy. Medical history includes gout and hypertension. Allergies: none. Current medications: allopurinol 100 mg PO daily (new), colchicine 0.6 mg PO daily (new), lisinopril 20 mg PO daily. Labs: SCr 1.2 mg/dL, AST 24 U/L, ALT 22 U/L. He asks when to start colchicine relative to allopurinol. What is the most appropriate dosing schedule for this patient?

A 74-year-old male (weight 76 kg) presents for a comprehensive medication review after a hospital discharge. Medical history: heart failure with reduced ejection fraction, hypertension, hyperlipidemia, benign prostatic hyperplasia (BPH). Allergies: none. Current medications: sacubitril/valsartan 49 mg/51 mg by mouth twice daily (new), lisinopril 20 mg by mouth daily (home med), furosemide 40 mg by mouth daily, metoprolol succinate 100 mg by mouth daily, atorvastatin 40 mg by mouth nightly, and tamsulosin 0.4 mg by mouth nightly. Pertinent labs: SCr 1.2 mg/dL (0.6–1.3), potassium 4.8 mEq/L (3.5–5.0), AST 26 U/L (10–40), ALT 22 U/L (7–56). Which medication should be discontinued based on current indications?