Drug Concentrations And Ratio Strengths Practice Test

A 52-year-old male (weight 90 kg) presents with an acute gout flare and requests a compounded topical NSAID for localized pain. Allergies: aspirin (bronchospasm). Current medications: allopurinol 300 mg PO daily, amlodipine 10 mg PO daily. Labs: SCr 1.0 mg/dL, AST 20 U/L, ALT 17 U/L, K 4.0 mEq/L. The prescriber requests diclofenac in a compounded gel at a ratio strength of 1:50 (w/w), total quantity 100 g. Calculate the ratio strength for this compounded medication in terms of grams of diclofenac required for the final product.

A 70-year-old man (weight 80 kg) is started on heparin for treatment of pulmonary embolism (high-alert medication). Allergies: none. Current medications: none. Labs: SCr 1.0 mg/dL, AST/ALT 26/24 units/L, platelets 210,000/mm$^3$, Na 138 mEq/L. The nurse requests a heparin infusion bag prepared as 25,000 units in 500 mL of 0.9% sodium chloride. What is the final concentration of the IV preparation?