Brain Structure, Neurotransmitters, and Behavior (7A) Practice Test
•15 QuestionsResearchers investigated histamine signaling and wakeful exploration. In a randomized trial, 64 participants received either a first-generation H1 antihistamine or placebo before completing a virtual-environment exploration task that required learning the locations of novel objects. The behavioral outcomes were total distance explored and later recognition accuracy for object locations. fMRI focused on posterior parietal cortex (PPC) during exploration and hippocampus during retrieval. The antihistamine reduced PPC activation during exploration and reduced total distance explored, while hippocampal activation during retrieval was not significantly different after controlling for exploration time. Which outcome is most consistent with the observed neurotransmitter effects?
Researchers investigated histamine signaling and wakeful exploration. In a randomized trial, 64 participants received either a first-generation H1 antihistamine or placebo before completing a virtual-environment exploration task that required learning the locations of novel objects. The behavioral outcomes were total distance explored and later recognition accuracy for object locations. fMRI focused on posterior parietal cortex (PPC) during exploration and hippocampus during retrieval. The antihistamine reduced PPC activation during exploration and reduced total distance explored, while hippocampal activation during retrieval was not significantly different after controlling for exploration time. Which outcome is most consistent with the observed neurotransmitter effects?