Lymphatic and Immune Systems (3B) Practice Test

A researcher injects an antigen into skin and observes that antigen-specific B cells proliferate mainly in follicles, while antigen-specific T cells proliferate mainly in the paracortex of the draining lymph node. Which cellular interaction best explains this compartmentalized response?

In a study of lymph flow, investigators apply rhythmic external compression to a subject’s lower leg while measuring clearance of a locally injected fluorescent tracer from the interstitial space. Clearance increases during compression. Based on the vignette, which is most consistent with the role of the lymphatic system?