Citric Acid Cycle and Oxidative Phosphorylation (1D) Practice Test

A pharmacologic inhibitor blocks the conversion of succinyl-CoA to succinate. In treated cells, succinyl-CoA increases while succinate decreases; OCR decreases modestly.

Which change would most likely increase ATP production under these conditions?

A compound inhibits citrate transport out of mitochondria. In proliferating cells, this leads to decreased cytosolic acetyl-CoA and increased mitochondrial citrate. OCR increases modestly.

Which mechanism most plausibly explains the increase in OCR?