0%
0 / 15 answered
Translation and Post-Translational Modification (1B) Practice Test
•15 QuestionsQuestion
1 / 15
Q1
A research group expressed a receptor-associated adaptor protein (Adap1) in mammalian cells. After stimulation with a growth factor, Adap1 shifted to a slower-migrating band on SDS-PAGE, and the shift was eliminated by phosphatase treatment. A mutant Adap1 in which a single serine in a consensus kinase motif was replaced with alanine failed to show the shift and showed prolonged receptor signaling. Based on the findings, what effect would the modification have on Adap1 function?
A research group expressed a receptor-associated adaptor protein (Adap1) in mammalian cells. After stimulation with a growth factor, Adap1 shifted to a slower-migrating band on SDS-PAGE, and the shift was eliminated by phosphatase treatment. A mutant Adap1 in which a single serine in a consensus kinase motif was replaced with alanine failed to show the shift and showed prolonged receptor signaling. Based on the findings, what effect would the modification have on Adap1 function?