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Master USMLE Step 1

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74 core skills 100% total weight

01

Amino Acid Metabolism And Urea Cycle

02

Biochemical Laboratory Techniques

03

Citric Acid Cycle And Oxidative Phosphorylation

04

DNA Structure, Replication, And Repair

05

Enzymes, Kinetics, And Regulation

06

Glycolysis, Gluconeogenesis, And Glycogen Metabolism

07

Inborn Errors Of Metabolism

08

Lipid Metabolism And Ketone Bodies

09

Mitochondrial Disorders And Energy Failure

10

Pentose Phosphate Pathway And Redox Balance

11

Transcription, Translation, And Regulation

12

Vitamins, Cofactors, And Nutrition

13

Bias And Confounding

14

Data Interpretation

15

Diagnostic Test Performance

16

Ethics And Research Principles

17

Risk Measures And Screening

18

Statistical Inference

19

Statistical Tests

20

Study Design And Evidence Types

21

Cardiac Pathophysiology

22

Cardiac Physiology And Hemodynamics

23

Vascular And Blood Pressure Disorders

24

Endocrine Pathophysiology

25

Hormone Physiology And Regulation

26

Metabolic And Growth Disorders

27

Gastrointestinal Pathophysiology

28

Gastrointestinal Physiology And Motility

29

Hepatobiliary And Pancreatic Pathophysiology

30

Cancer Genetics

31

Chromosomal Disorders

32

Genetic Testing And Diagnostics

33

Inherited Metabolic And Single-Gene Disorders

34

Mendelian Inheritance And Pedigrees

35

Mitochondrial And Non-Mendelian Inheritance

36

Molecular Genetics And Gene Expression

37

Cancer Biology And Neoplasia

38

Hematologic Physiology And Disorders

39

Antigen Presentation And Cytokines

40

Autoimmunity And Self-Tolerance

41

HIV And Retroviruses

42

Hypersensitivity Reactions

43

Immunodeficiency Disorders

44

Innate And Adaptive Immunity

45

Transplantation Immunology

46

Vaccines And Immune Memory

47

Antimicrobial Mechanisms

48

Antimicrobial Resistance

49

Bacterial Structure, Classification, And Virulence

50

Bacterial Toxins And Immune Evasion

51

Fungi And Parasites

52

Host–Pathogen Interactions

53

Microbial Laboratory Identification

54

Viral Structure And Replication

55

Neuroanatomy And Localization

56

57

Neurophysiology

58

Antimicrobial Pharmacology

59

Autonomic Pharmacology

60

Cardiovascular Pharmacology

61

Central Nervous System Pharmacology

62

Drug Toxicity And Adverse Effects

63

Endocrine Pharmacology

64

Pharmacodynamics And Receptor Theory

65

Pharmacokinetics

66

Toxicology And Antidotes

67

Acid–Base And Electrolyte Regulation

68

Renal Pathophysiology

69

Renal Physiology And Filtration

70

Reproductive Pathophysiology

71

Reproductive Physiology And Development

72

Control Of Breathing And Regulation

73

Pulmonary Pathophysiology

74

Respiratory Physiology And Gas Exchange