Certified Professional Coder (CPC) Quiz: Code Infusion And Chemotherapy
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Code Infusion And ChemotherapyQuestion 1 of 20

Which add-on CPT® code is reported for each additional hour of hydration beyond the first hour?

96361
96360
96366
96365
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Certified Professional Coder (CPC) Quiz

Certified Professional Coder (CPC) Quiz: Code Infusion And Chemotherapy

Practice Code Infusion And Chemotherapy in Certified Professional Coder (CPC) with focused quiz questions that help you check what you know, review explanations, and build confidence with test-style prompts.

What this quiz covers

This quiz focuses on Code Infusion And Chemotherapy, giving you a quick way to practice the rules, question types, and explanations that matter most for Certified Professional Coder (CPC).

How to use this quiz

Try each quiz question before looking at the correct answer. Use the explanations to review missed ideas, then come back to similar questions until the pattern feels familiar.

All questions

Question 1

Which add-on CPT® code is reported for each additional hour of hydration beyond the first hour?

  1. 96361 (correct answer)
  2. 96360
  3. 96366
  4. 96365
Explanation: CPT® 96361 describes intravenous infusion for hydration, each additional hour (add-on to 96360) — the correct add-on code for every additional hour of plain IV fluid hydration beyond the initial 31-to-60-minute period captured by 96360. For a total hydration time of 1 hour 45 minutes, the reporting is 96360 (initial, 31 to 60 min) plus one unit of 96361 (for the additional 45 minutes beyond the first hour). Code 96360 is the primary hydration code and cannot be reported as an add-on. Code 96366 is the add-on for additional hours of therapeutic infusion (non-hydration); plain saline without medication is hydration, not therapeutic infusion. Code 96365 is the primary therapeutic infusion code. CPT® 96361 is an add-on code and must always be reported in conjunction with 96360 as the primary code.

Question 2

Which CPT® code is reported for this initial IV drug infusion?

  1. 96360
  2. 96365 (correct answer)
  3. 96374
  4. 96372
Explanation: CPT® 96365 describes the initial intravenous infusion of a therapeutic, prophylactic, or diagnostic drug or substance, up to 1 hour — the correct code when a medication (methylprednisolone) is administered by infusion over a period greater than 15 minutes. Code 96360 describes IV hydration with plain fluid only; methylprednisolone is a therapeutic medication, not a hydration fluid. Code 96374 describes an IV push, which applies when a drug is administered in 15 minutes or less; the methylprednisolone is infused over 50 minutes, making 96365 appropriate. Code 96372 describes a subcutaneous or intramuscular injection; the route here is intravenous infusion. CPT guidelines define an infusion as a drug administered over more than 15 minutes; services of 15 minutes or less are reported as an IV push.

Question 3

Which CPT® code is reported for this chemotherapy injection?

  1. 96372
  2. 96365
  3. 96409
  4. 96401 (correct answer)
Explanation: CPT® 96401 describes chemotherapy administration by subcutaneous or intramuscular injection of a non-hormonal antineoplastic agent — the correct code when a chemotherapy drug is administered by the IM or SC route. Methotrexate at high doses for acute leukemia is an antineoplastic chemotherapy agent given by intramuscular injection, requiring the chemotherapy-specific administration code. Code 96372 describes IM or SC injection of a non-chemotherapy therapeutic substance; CPT guidelines specify that chemotherapy administration must be reported with the chemotherapy codes (9640x series), not the general injection codes. Code 96365 describes IV infusion; the route here is intramuscular, not intravenous. Code 96409 describes chemotherapy administered as an IV push; the route here is IM. When any recognized antineoplastic chemotherapy drug is administered, the chemotherapy administration hierarchy applies.

Question 4

Which CPT® code reports the mesna as a sequential non-chemotherapy infusion following the primary chemotherapy?

  1. 96365
  2. 96366
  3. 96415
  4. 96367 (correct answer)
Explanation: CPT® 96367 describes additional sequential infusion of a new drug or substance different from the primary service substance, up to 1 hour — the add-on code used when a non-chemotherapy drug is infused sequentially after any primary infusion (including chemotherapy). Mesna is not a chemotherapy agent; it is a uroprotective drug given after cyclophosphamide. Since mesna is administered sequentially after the chemotherapy ends, 96367 is the appropriate add-on code even when the primary infusion was chemotherapy (96413). Code 96365 is a primary therapeutic infusion code, not an add-on; when chemotherapy is the primary service, non-chemo drugs given sequentially use 96367 as the add-on. Code 96366 describes additional hours of the same primary therapeutic drug; mesna is a different drug. Code 96415 is the chemotherapy-specific add-on for additional hours of the same chemo drug; mesna is not a chemotherapy drug.

Question 5

Which CPT® code reports the doxorubicin as an additional sequential chemotherapy IV push of a different drug?

  1. 96409
  2. 96374
  3. 96411 (correct answer)
  4. 96375
Explanation: CPT® 96411 describes chemotherapy administration by IV push, each additional sequential injection of a new drug or substance (add-on to 96409) — the correct add-on code when a second chemotherapy agent is given as a separate IV push following the initial chemotherapy push. Doxorubicin is a chemotherapy drug administered sequentially by IV push after the vincristine push is complete, requiring the chemotherapy-specific additional push code. Code 96409 is the primary chemotherapy IV push code; it cannot be reported a second time for the same encounter's additional sequential push. Code 96374 describes IV push of a non-chemotherapy therapeutic drug; doxorubicin is a chemotherapy agent, requiring the chemotherapy push code. Code 96375 describes an additional sequential IV push of a different non-chemotherapy drug; chemotherapy requires 96411, not 96375.

Question 6

Which add-on CPT® code reports the dexamethasone as a sequential IV push of a different drug?

  1. 96374
  2. 96376
  3. 96375 (correct answer)
  4. 96368
Explanation: CPT® 96375 describes each additional sequential IV push of a new drug or substance, different from the drug reported as the initial push — the correct add-on code when a second drug is given as a separate IV push in sequence after the initial push is complete. Dexamethasone is a different drug from ondansetron, administered sequentially (not simultaneously), making 96375 the correct add-on to the primary 96374. Code 96374 is the primary IV push code and may not be repeated for a second different drug in the same session; the add-on 96375 captures subsequent different-drug pushes. Code 96376 describes an additional sequential IV push of the same drug (identical substance); dexamethasone and ondansetron are different drugs. Code 96368 describes a concurrent (simultaneous) infusion, not a sequential push. The key differentiators: 96375 = different drug, sequential push; 96376 = same drug, sequential push (>30 min interval).

Question 7

Which CPT® code reports the lorazepam administered concurrently with the primary ondansetron infusion?

  1. 96367
  2. 96368 (correct answer)
  3. 96374
  4. 96375
Explanation: CPT® 96368 describes a concurrent infusion — the administration of a different drug or substance simultaneously with a primary infusion via the same IV line or access — and is reported only once per encounter regardless of the number of concurrent drugs. Lorazepam is given at the same time as (not sequentially after) the primary ondansetron infusion, making 96368 the correct code. Code 96367 describes additional sequential infusion of a different drug that begins after the primary infusion ends; since lorazepam runs simultaneously (not sequentially), 96367 is incorrect. Code 96374 describes a single IV push of a drug administered over 15 minutes or less; the lorazepam here is running concurrently as an infusion, not as a separate push. Code 96375 describes a sequential IV push of an additional different drug after a prior push; concurrent simultaneous infusion is not a sequential push.

Question 8

Which CPT® code is reported as the primary service for this encounter?

  1. 96360 (correct answer)
  2. 96365
  3. 96361
  4. 96366
Explanation: CPT® 96360 describes intravenous infusion for hydration, initial, 31 minutes to 1 hour — the correct primary code when plain IV fluid (without medication) is administered for hydration and the infusion time is between 31 and 60 minutes. Lactated Ringer solution without added medication is a hydration fluid. Code 96365 describes initial IV infusion of a therapeutic, prophylactic, or diagnostic drug substance; plain IV fluid without medication does not constitute a therapeutic drug infusion. Code 96361 is an add-on code (each additional hour of hydration) and cannot function as a standalone primary code. Code 96366 is an add-on code for each additional hour of therapeutic infusion. For this encounter, the infusion time (40 minutes) falls squarely in the 31-to-60-minute window for 96360, and no medication is administered, confirming 96360 as the sole reportable code.

Question 9

Which CPT® code is reported for this initial chemotherapy IV push?

  1. 96409 (correct answer)
  2. 96374
  3. 96413
  4. 96411
Explanation: CPT® 96409 describes chemotherapy administration by IV push, single or initial substance — the correct code when a chemotherapy drug is directly injected into a vein or established line over 15 minutes or less. Vincristine is an antineoplastic vinca alkaloid administered over 10 minutes, meeting both the chemotherapy and IV push criteria. Code 96374 describes IV push of a non-chemotherapy therapeutic drug; vincristine is a chemotherapy agent, and CPT guidelines require use of the chemotherapy-specific push code (96409) rather than the general therapeutic push code. Code 96413 describes chemotherapy administered by IV infusion over more than 15 minutes; vincristine is given over 10 minutes, classifying it as a push rather than an infusion. Code 96411 is the add-on for additional sequential chemotherapy IV push of a different drug; it cannot be reported without a primary 96409 and does not apply as a standalone initial code.

Question 10

Which CPT® code reports the diphenhydramine as the first service, with infliximab reported as the add-on sequential infusion of a different drug?

  1. 96366
  2. 96367 (correct answer)
  3. 96368
  4. 96365
Explanation: CPT® 96367 describes additional sequential infusion of a new drug or substance (different from the primary), up to 1 hour — the add-on code reported for the second (or later) drug infused in sequence after the primary infusion ends. In this scenario, infliximab is the sequential infusion following the completion of diphenhydramine; 96367 is appended to the primary 96365 for diphenhydramine to report the infliximab as a sequential different-drug infusion. In clinical practice, infliximab (as the therapeutically primary drug) would typically be the primary 96365, with diphenhydramine as 96367, since the hierarchically more complex service drives the primary code. Code 96366 adds hours to the same drug; code 96368 is for concurrent (simultaneous) infusion; code 96365 is the primary infusion of the initial drug.

Question 11

Which CPT® code is reported for this IV hydration service?

  1. 96360 (correct answer)
  2. 96365
  3. 96361
  4. 96366
Explanation: CPT® 96360 describes intravenous infusion for hydration, initial, 31 minutes to 1 hour — the correct code when plain intravenous fluid (without medication) is administered for hydration purposes and the infusion lasts between 31 and 60 minutes. Code 96365 describes the initial hour of a therapeutic, prophylactic, or diagnostic IV infusion of a drug or substance; plain normal saline without added medication is not a therapeutic drug infusion. Code 96361 is the add-on code for each additional hour of hydration beyond the first hour; it cannot be reported as a standalone code. Code 96366 is the add-on code for each additional hour of therapeutic infusion; it also cannot be reported as a primary code. The key distinction between 96360 and 96365 is that 96360 is for plain fluid hydration with no medication, while 96365 applies when a drug or other therapeutic substance is being infused.

Question 12

Which add-on CPT® code is reported for each additional hour of chemotherapy infusion beyond the first hour?

  1. 96415 (correct answer)
  2. 96366
  3. 96417
  4. 96367
Explanation: CPT® 96415 describes chemotherapy administration by intravenous infusion, each additional hour (add-on to 96413) — the correct code for every hour of chemotherapy infusion beyond the first hour already captured by 96413. Code 96415 is an add-on code and may only be reported in conjunction with 96413 as the primary service. Code 96366 describes each additional hour of a non-chemotherapy therapeutic infusion (add-on to 96365); since oxaliplatin is a chemotherapy agent, the chemotherapy-specific add-on (96415) must be used. Code 96417 describes an additional sequential chemotherapy infusion of a new drug/substance — not an additional hour of the same drug. Code 96367 describes sequential infusion of a different non-chemo substance. For a 2-hour oxaliplatin infusion, the correct reporting is 96413 for the first hour plus one unit of 96415 for the second hour.

Question 13

Which CPT® code is reported for the initial 1-hour paclitaxel chemotherapy infusion?

  1. 96365
  2. 96401
  3. 96413 (correct answer)
  4. 96409
Explanation: CPT® 96413 describes chemotherapy administration by intravenous infusion, initial, up to 1 hour — the correct code for the first hour of any IV infusion of a chemotherapy agent. Paclitaxel is an antineoplastic chemotherapy drug administered by intravenous infusion, which requires a chemotherapy-specific administration code rather than a generic therapeutic infusion code. Code 96365 describes initial IV infusion of a non-chemotherapy therapeutic substance; chemotherapy administration codes (9640x/9641x series) take precedence and must be used for antineoplastic agents. Code 96401 describes chemotherapy administration by the subcutaneous or intramuscular route; paclitaxel is given intravenously here. Code 96409 describes chemotherapy given as an IV push (15 minutes or less); the paclitaxel infusion runs over 1 hour, requiring 96413.

Question 14

Which CPT® code is reported for this intramuscular injection?

  1. 96374
  2. 96401
  3. 96372 (correct answer)
  4. 96369
Explanation: CPT® 96372 describes therapeutic, prophylactic, or diagnostic injection into subcutaneous or intramuscular tissue — the correct code for any IM or SC injection of a non-chemotherapy drug administered in a clinical setting. Penicillin G benzathine is an antibiotic (not a chemotherapy agent), administered intramuscularly, making 96372 appropriate. Code 96374 describes an intravenous push; the route here is intramuscular, not intravenous. Code 96401 describes chemotherapy administration by the subcutaneous or intramuscular route; penicillin is not a chemotherapy or antineoplastic agent. Code 96369 describes a subcutaneous infusion (pump-delivered) for therapeutic purposes lasting up to 1 hour; this is a single injection, not a subcutaneous infusion. Code 96372 applies to all IM and SC injections of non-chemotherapy therapeutic, prophylactic, or diagnostic substances.

Question 15

Per CPT® infusion hierarchy rules, which code is reported as the primary service for this encounter?

  1. 96365
  2. 96367
  3. 96365 and 96413
  4. 96413 (correct answer)
Explanation: CPT® 96413 is reported as the primary service because chemotherapy administration is the highest level in the infusion service hierarchy and takes primary code precedence regardless of the order in which drugs are administered during the encounter. When chemotherapy and non-chemotherapy infusion services occur in the same session, the chemotherapy code (96413) is always the primary code. Ondansetron is then reported as the sequential infusion add-on (96367) even though it was given first. Code 96365 may not be reported as the primary when chemotherapy is administered in the same encounter. Reporting both 96365 and 96413 as co-primary codes is incorrect per CPT® hierarchy guidelines. The hierarchy order is: chemotherapy administration (highest) > therapeutic/prophylactic/diagnostic infusion > hydration (lowest). The drug with the highest service level drives the primary code selection.

Question 16

Which add-on CPT® code reports the second administration of the same drug as a sequential IV push?

  1. 96374
  2. 96376 (correct answer)
  3. 96375
  4. 96367
Explanation: CPT® 96376 describes each additional sequential IV push of the same drug or substance at intervals of greater than 30 minutes from the prior push — the correct add-on code when the identical drug is re-administered by IV push after a gap of more than 30 minutes from the initial push. Both the drug identity (metoclopramide) and the time interval (75 minutes after the first push) satisfy the criteria for 96376. Code 96374 is the primary IV push code and may not be reported again for a second push of the same drug in the same session; the add-on code 96376 is used instead. Code 96375 describes a sequential IV push of a different drug — the second push here is the same drug (metoclopramide), not a different drug. Code 96367 describes sequential IV infusion (not push) of a different substance. The 30-minute interval and same-drug identity are the dual criteria for 96376.

Question 17

Which CPT® code reports this initial subcutaneous therapeutic infusion?

  1. 96365
  2. 96372
  3. 96369 (correct answer)
  4. 96374
Explanation: CPT® 96369 describes subcutaneous infusion for therapeutic purposes, initial, up to 1 hour — the correct code when a drug is delivered by continuous infusion via the subcutaneous (not intravenous) route. Subcutaneous immunoglobulin administered via pump-driven subcutaneous infusion over 55 minutes is the paradigmatic example. Code 96365 describes initial intravenous (not subcutaneous) therapeutic infusion; the route here is subcutaneous. Code 96372 describes a single subcutaneous or intramuscular injection; this is a prolonged continuous subcutaneous infusion via pump, not a single injection. Code 96374 describes an intravenous push; no IV access is used here. Subcutaneous infusion has its own distinct code series (96369-96371) separate from both IV infusion codes (96365-96368) and injection codes (96372).

Question 18

Which CPT® code is reported for this chemotherapy administration route?

  1. 96401
  2. 96413
  3. 96409
  4. 96420 (correct answer)
Explanation: CPT® 96420 describes chemotherapy administration by intracavitary instillation using an intracavitary pressure technique — the correct code for chemotherapy delivered directly into a body cavity (peritoneal, pleural, or bladder) via intracavitary pressure rather than by systemic IV or injection. Intraperitoneal cisplatin as part of HIPEC or standard IP chemotherapy is the canonical example. Code 96401 describes subcutaneous or intramuscular chemotherapy injection; the route here is intraperitoneal (intracavitary), not IM or SC. Code 96413 describes intravenous chemotherapy infusion; the drug is delivered intraperitoneally, not intravenously. Code 96409 describes IV chemotherapy push; again, the route is intraperitoneal. Correctly identifying the route of administration — intraperitoneal via intracavitary pressure — is essential to selecting 96420.

Question 19

May the concurrent normal saline hydration be separately reported in addition to the primary chemotherapy infusion?

  1. Yes, report 96360 with modifier 59
  2. Yes, report 96361 as the concurrent hydration add-on
  3. Yes, report 96368 for the concurrent hydration
  4. No, concurrent hydration is not separately reportable when a more complex infusion service is the primary service (correct answer)
Explanation: Per CPT® infusion guidelines, hydration (96360/96361) administered concurrently with or as a secondary service to a primary therapeutic or chemotherapy infusion is not separately reportable. Hydration that exists solely to support the administration of the primary drug (vein patency, prehydration, post-hydration as part of the chemotherapy protocol) is considered incidental to the primary infusion service and is bundled into it. Modifier 59 does not override this bundling rule when the hydration is not a distinct, separately indicated service. Code 96361 is an add-on for hydration-only encounters, not for concurrent hydration during a more complex service. Code 96368 applies to concurrent infusion of a different drug substance, not plain hydration fluid without a distinct therapeutic purpose. Hydration is only separately reportable when it is the primary or standalone service of the encounter.

Question 20

Which CPT® code is reported for this intramuscular injection?

  1. 96374
  2. 96372 (correct answer)
  3. 96369
  4. 96365
Explanation: CPT® 96372 describes therapeutic, prophylactic, or diagnostic injection — subcutaneous or intramuscular — the correct code for any IM or SC injection of a non-chemotherapy substance. Promethazine is an antiemetic medication (not chemotherapy) administered by the intramuscular route, making 96372 the appropriate code. Code 96374 describes an IV push; no intravenous access is established and the drug is given intramuscularly, not intravenously. Code 96369 describes subcutaneous infusion via pump delivery over time; this is a single injection, not a pump-driven subcutaneous infusion. Code 96365 describes IV infusion; the route here is intramuscular. Code 96372 covers the broadest range of single-injection services for non-chemotherapy drugs regardless of the IM or SC route.