USMLE Step 3 Quiz
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CRITICAL CARE
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A 33-year-old woman with systemic lupus erythematosus (SLE) is admitted to the ICU with diffuse alveolar hemorrhage. She is intubated and requires high FiO2. She is started on high-dose steroids and plasmapheresis. Despite this, she develops oliguric acute kidney injury and shock requiring norepinephrine. Her anti-double-stranded DNA antibody titers are markedly elevated, and her complement levels are low.
The patient's poor prognosis is best understood as a failure of which of the following?
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