USMLE Step 2 Quiz
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A 17-year-old boy is evaluated for persistent microscopic hematuria discovered on a pre-participation sports physical. His family history is notable for an uncle and a maternal cousin who developed end-stage renal disease before age 30. On further questioning, the patient admits to some difficulty hearing his teachers in class. An audiogram confirms bilateral sensorineural hearing loss. Ophthalmic examination is normal.
This patient's condition results from a genetic defect affecting the synthesis of which of the following proteins?
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