USMLE Step 1 Quiz
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RENAL SYSTEM
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A 55-year-old man with small cell lung cancer presents with confusion and lethargy. Laboratory studies reveal a serum sodium of 122 mEq/L, low plasma osmolality, and inappropriately concentrated urine. He is diagnosed with Syndrome of Inappropriate Antidiuretic Hormone (SIADH).
The concentrated urine in this patient is a direct result of antidiuretic hormone (ADH) increasing the permeability of the medullary collecting duct to which of the following substances?
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