USMLE Step 1 Quiz
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NERVOUS SYSTEM
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A 67-year-old man with essential tremor undergoes deep brain stimulation (DBS) electrode placement in the ventral intermediate nucleus of the thalamus. High-frequency stimulation (130 Hz) dramatically reduces his tremor, but the effect disappears immediately when stimulation is stopped. Researchers note that this frequency of stimulation paradoxically suppresses neuronal firing in the target region. Which of the following mechanisms best explains how high-frequency stimulation reduces tremor despite suppressing local neuronal activity?
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