USMLE Step 1 Quiz
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GASTROINTESTINAL SYSTEM
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A 35-year-old man with a 10-year history of ulcerative colitis presents with progressive fatigue and itching. Laboratory tests reveal an elevated alkaline phosphatase and total bilirubin. An endoscopic retrograde cholangiopancreatography (ERCP) shows multiple strictures and dilatations of the intrahepatic and extrahepatic bile ducts, creating a 'beads on a string' appearance.
This patient's hepatobiliary disease is strongly associated with the presence of which of the following antibodies?
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