USMLE Step 1 Quiz
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HEMATOLOGY AND ONCOLOGY
Question 1 of 20
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A 22-year-old African American man with a history of sickle cell disease presents to the emergency department with severe pain in his back and legs. He reports the pain began suddenly this morning. His temperature is 37.5°C (99.5°F), pulse is 110/min, and blood pressure is 130/80 mm Hg. Physical examination reveals tenderness to palpation over the lumbar spine and bilateral tibias. Laboratory studies show a hemoglobin of 8.2 g/dL. This patient's underlying disease is caused by a point mutation in the β-globin gene.
This mutation results in the substitution of which of the following amino acids?
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