USMLE Step 1 Quiz
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PHARMACOLOGY
Question 1 of 20
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A 48-year-old man with chronic gout starts allopurinol. One month later he develops a diffuse painful maculopapular rash that becomes blistering with mucosal involvement; biopsy shows full-thickness epidermal necrosis. Laboratory studies reveal eosinophilia and elevated alanine transaminase. Which genetic factor most strongly predisposed this patient to the described adverse reaction?
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