USMLE Step 1 Quiz
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IMMUNOLOGY
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A 5-year-old boy presents with massive, non-malignant lymphadenopathy, splenomegaly, and autoimmune hemolytic anemia. Laboratory analysis reveals an elevated number of T cells in his peripheral blood that are negative for both CD4 and CD8. Further investigation shows a mutation in the gene encoding Fas.
The accumulation of lymphocytes and subsequent autoimmunity in this patient is due to a failure of which of the following processes?
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