Pharmacology Quiz
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TOXICOLOGY & SPECIAL POPULATIONS
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A 62-year-old patient undergoes coronary artery bypass grafting with cardiopulmonary bypass, for which high-dose unfractionated heparin is used. Post-operatively, heparin is reversed with protamine sulfate, and the activated clotting time (ACT) normalizes. Six hours later, the patient's chest tube output increases significantly, and the aPTT is found to be prolonged. What is the most likely cause of this coagulopathy?
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