Pharmacology Quiz
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ANTI-INFECTIVES
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A patient with an MRSA prosthetic knee infection has been receiving IV vancomycin for four weeks with therapeutic trough concentrations. Despite this, the patient shows minimal clinical improvement, with persistent joint effusion and elevated inflammatory markers. A repeat aspirate culture grows MRSA with a vancomycin MIC of 2 mcg/mL, reported as 'Susceptible' by the lab.
Which of the following best explains the likely reason for treatment failure in this patient?
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