Pharmacology Quiz
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TOXICOLOGY & SPECIAL POPULATIONS
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Paramedics respond to a person found in cardiac arrest at home, surrounded by drug paraphernalia. They perform CPR and administer a total of 12 mg of intravenous naloxone over 15 minutes. Despite these efforts and advanced cardiac life support, the patient never achieves return of spontaneous circulation.
What is the most plausible explanation for the complete lack of response to high-dose naloxone in this scenario?
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