Pharmacology Quiz
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PRINCIPLES OF PHARMACOLOGY
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A drug is administered orally every 12 hours. Its half-life is 12 hours, and it follows first-order kinetics. The dosing regimen is changed to give the same total daily dose, but now administered every 24 hours (i.e., double the dose, once a day). How will this change affect the average steady-state concentration (Css,avg) and the fluctuation between peak and trough concentrations at steady state?
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